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Tropomyosin 1 (Alpha) Proteins (TPM1)

TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Additionally we are shipping Tropomyosin 1 (Alpha) Antibodies (41) and Tropomyosin 1 (Alpha) Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TPM1 7168 P09493
TPM1 22003 P58771
TPM1 24851 P04692
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Top Tropomyosin 1 (Alpha) Proteins at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$327.80
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,482.33
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Yeast Hydrozoa His tag   1 mg Log in to see 56 to 66 Days
$2,616.17
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Yeast Hydra His tag   1 mg Log in to see 56 to 66 Days
$2,651.00
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Yeast Biomphalaria glabrata His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
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Yeast Schistosoma mansoni His tag   1 mg Log in to see 56 to 66 Days
$2,746.33
Details

TPM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Tropomyosin 1 (Alpha) Proteins

  1. Human TPM1 Protein expressed in Escherichia coli (E. coli) - ABIN667191 : Perry: Vertebrate tropomyosin: distribution, properties and function. in Journal of muscle research and cell motility 2001 (PubMed)
    Show all 2 references for ABIN667191

More Proteins for Tropomyosin 1 (Alpha) (TPM1) Interaction Partners

Rabbit Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. Maximal Ca(2 (show CA2 Proteins)+) activated force was the same in alphaalphaTm versus betabetaTm myofibrils, but betabetaTm myofibrils showed a marked slowing of relaxation and an impairment of regulation under resting conditions

  2. Tmod1 (show TMOD1 Proteins) and Tmod3 (show TMOD3 Proteins) showed somewhat different tropomyosin (show TPM2 Proteins)-binding site utilization.

  3. Thermal denaturation of rabbit cardiac alpha,alpha-tropomyosin is monitored at neutral pH and compared to shark tropomyosin (show TPM2 Proteins), showing that amino acid substitutions predicted to be unfavorable in one temperature regime are desirable in another.

  4. The rotational motion of a spin label covalently bound to the side chain of a cysteine genetically incorporated into rabbit skeletal muscle tropomyosin (show TPM2 Proteins), was measured.

  5. a computational search assessing electrostatic interactions for multiple azimuthal locations, z-positions, and pseudo-rotations of tropomyosin on F-actin was performed.

Human Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The TPM1 (rs1071646) and TNNT2 (show TNNT2 Proteins) (rs3729547) gene variants might represent risk factors for patients with dilated cardiomyopathy in the Kazakh population.

  2. The mutation reduced binding affinity for both Lmod2 (show LMOD2 Proteins) and Tmod1 (show TMOD1 Proteins). The effect of the K15N mutation on Tpm1.1 binding to Lmod2 (show LMOD2 Proteins) and Tmod1 (show TMOD1 Proteins) provides a molecular rationale for the development of familial dilated cardiomyopathies .

  3. Data confirm that the substitutions of the Tpm1 residues G126 and D137 with the canonical ones, Arg and Leu, respectively, increase the stiffness of the Tpm (show TPMT Proteins) coiled-coil

  4. these results indicate that TPM1 may be one mechanism underlying radiation resistance, and TPM1 may be a potential target for overcoming the radiation resistance in glioma.

  5. Mitochondrial RNA induces tropomyosin (show TPM2 Proteins) synthesis.

  6. TPM1 exhibits characteristics of a tumor-suppressor gene while being overexpressed in Renal cell carcinoma (show MOK Proteins) cell lines.

  7. We have quantified the expression of the total sarcomeric TPM1 and observed a 1.5-fold increase in treated cells.

  8. Coexistence of Digenic Mutations in Both TPM1 and MYH7 (show MYH7 Proteins) Genes Leads to Severe Hypertrophic Cardiomyopathy.

  9. Mutant TPM1cause m ultiple functional alterations in actin affinity and Ca2 (show CA2 Proteins)+ sensitivity.

  10. Development of pathological hypertrophy did not occur in mice expressing both Tm180 and TnI (show TNNI2 Proteins)-PP.

Pig (Porcine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. The tendency of smooth muscle tropomyosin to form semi-rigid polymers with continuous and undampened rigidity may compensate for the lack of troponin-based structural support in smooth muscles.

  2. Deletion of regions 2-3 in tropomyosin (show TPM2 Proteins) alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin (show TPM2 Proteins)-reconstituted myocardium.

  3. Tropomyosin (show TPM2 Proteins) is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle.

  4. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Mouse (Murine) Tropomyosin 1 (Alpha) (TPM1) interaction partners

  1. three-dimensional structure of F-actin at a resolution of 3.7 A in complex with tropomyosin (show TPM2 Proteins) at a resolution of 6.5 A, determined by electron cryomicroscopy

  2. data also identify a novel alphaTM1/Tmod1-based pathway stabilizing F-actin at cell-cell junctions, which may be required for maintenance of cell shapes during embryonic cardiac morphogenesis.

  3. This is the first study to demonstrate that decreasing phosphorylation of tropomyosin (show TPM2 Proteins) can rescue a hypertrophic cardiomyopathic phenotype.

  4. Tropomyosin (show TPM2 Proteins) dephosphorylation results in myocyte hypertrophy with increases in SERCA2a (show ATP2A2 Proteins) expression.

  5. The results identify a novel mode of myofilament desensitization to Ca(2 (show CA2 Proteins)+) associated with a DCM linked switch in TPM1-kappa.

  6. signaling by alpha-tropomyosin may have a role in familial hypertrophic cardiomyopathy

  7. A point mutation in alpha-TM causes a disease similar to familial hypertophic cardiomyopahy.

  8. PTB (show PTBP1 Proteins) interacting protein raver1 (show RAVER1 Proteins) regulates alpha-tropomyosin alternative splicing.

  9. the N terminus is a critical determinant of TM1 (show TPM2 Proteins) functions, which in turn determines the organization of stress fibers.

  10. charge changes at the carboxy-terminal of alpha-TM alter the functional characteristics of the heart at both the whole organ and myofilament levels.

Tropomyosin 1 (Alpha) (TPM1) Protein Profile

Protein Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.

Gene names and symbols associated with Tropomyosin 1 (Alpha) Proteins (TPM1)

  • alpha-tropomyosin (LOC100125989)
  • alpha-tropomyosin (tpma)
  • tropomyosin (tm7)
  • tropomyosin (Smp_044010.2)
  • tropomyosin 1 (LOC732984)
  • tropomyosin 1 (alpha) (TPM1)
  • tropomyosin 1 (alpha) (tpm1)
  • tropomyosin 1, alpha (Tpm1)
  • AA986836 protein
  • AI854628 protein
  • alpha-fTM protein
  • Alpha-tm protein
  • alpha-tropomyosin protein
  • C15orf13 protein
  • CH1 protein
  • CMD1Y protein
  • CMH3 protein
  • fb37a09 protein
  • HTM-alpha protein
  • MGC84844 protein
  • tm protein
  • TM2 protein
  • Tm3 protein
  • Tm7 protein
  • Tma2 protein
  • Tmpa protein
  • Tmsa protein
  • Tpm-1 protein
  • tpm1 protein
  • TPMA protein
  • wu:fb37a09 protein

Protein level used designations for Tropomyosin 1 (Alpha) Proteins (TPM1)

tropomyosin alpha-1 chain , tropomyosin , Tropomyosin-1 alpha chain , tropomyosin-1 , alpha-tropomyosin 1 , alpha-tropomyosin 2 , alpha-tropomyosin of skeletal fast muscle , tropomyosin (CTm4) , tropomyosin (CTm7) , alpha-tropomyosin , cardiomyopathy, hypertrophic 3 , sarcomeric tropomyosin kappa , tropomyosin 1 (alpha) isoform 1 , tropomyosin 1 (alpha) isoform 2 , tropomyosin 1 (alpha) isoform 3 , tropomyosin 1 (alpha) isoform 4 , tropomyosin 1 (alpha) isoform 5 , tropomyosin 1 (alpha) isoform 6 , tropomyosin 1 (alpha) isoform 7 , tropomyosin 1 alpha chain , alpha-skeletal tropomyosin , alpha tropomyosin , hepatoma alpha tropomyosin , smooth muscle alpha-tropomyosin , striated muscle alpha-tropomyosin , tropomyosin 3 alpha

GENE ID SPECIES
100125989 Oryctolagus cuniculus
30324 Danio rerio
431788 Xenopus laevis
8350314 Schistosoma mansoni
732984 Bombyx mori
396366 Gallus gallus
7168 Homo sapiens
100037999 Sus scrofa
281544 Bos taurus
100189579 Xenopus laevis
478332 Canis lupus familiaris
22003 Mus musculus
24851 Rattus norvegicus
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