anti-Troponin T2, Cardiac (TNNT2) Antibodies

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Additionally we are shipping Cardiac Troponin T2 Kits (72) and Cardiac Troponin T2 Proteins (36) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNNT2 7139 P45379
TNNT2 24837 P50753
TNNT2 21956 P50752
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Top anti-Cardiac Troponin T2 Antibodies at antibodies-online.com

Showing 10 out of 383 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TNNT2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the TNNT2 antibody detected the TNNT2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of cTnT expression in H9 (A), 4T1 (B), human heart (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Cat Mouse Un-conjugated EIA, IHC (p), IP, WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Chicken Mouse Un-conjugated IF, IHC (p) Human Rabbit Heart (formalin-fixed, paraffin-embedded) stained with TNNT2 antibody ABIN462337 followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 7 to 9 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB   0.2 mL Log in to see 7 to 9 Days
$408.19
Details
Chicken Mouse Un-conjugated IF, IHC (p) 250 μL Log in to see 7 to 9 Days
$676.50
Details
Cat Mouse Un-conjugated IHC (p), ELISA Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Cat Mouse Un-conjugated IHC (p), ELISA Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$451.00
Details
Human Mouse Un-conjugated EIA, WB 0.2 mg Log in to see 6 to 8 Days
$401.50
Details

TNNT2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Cardiac Troponin T2 Antibodies

  1. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody for ICS - ABIN2688864 : Jáchymová, Muravská, Paleček, Kuchynka, Řeháková, Magage, Kr��l, Zima, Horký, Linhart: Genetic variation screening of TNNT2 gene in a cohort of patients with hypertrophic and dilated cardiomyopathy. in Physiological research / Academia Scientiarum Bohemoslovaca 2012 (PubMed)
    Show all 7 Pubmed References

  2. Chicken Monoclonal Cardiac Troponin T2 Primary Antibody for IHC (f), ICS - ABIN2688865 : Lian, Hsiao, Wilson, Zhu, Hazeltine, Azarin, Raval, Zhang, Kamp, Palecek: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 7 Pubmed References

  3. Fish Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Detection), ELISA - ABIN191344 : Feng, Taggart, Hall, Bryant, Sansone, Kemmerer, Herlich, Lord: Limited additional release of cardiac troponin I and T in isoproterenol-treated beagle dogs with cardiac injury. in Clinical chemistry 2005 (PubMed)
    Show all 6 Pubmed References

  4. Mammalian Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Capture), ELISA - ABIN191341 : Goette, Arndt, Röcken, Staack, Bechtloff, Reinhold, Huth, Ansorge, Klein, Lendeckel: Calpains and cytokines in fibrillating human atria. in American journal of physiology. Heart and circulatory physiology 2002 (PubMed)
    Show all 6 Pubmed References

  5. Fish Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA, WB - ABIN191342 : Hammerer-Lercher, Erlacher, Bittner, Korinthenberg, Skladal, Sorichter, Sperl, Puschendorf, Mair: Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy. in Clinical chemistry 2001 (PubMed)
    Show all 6 Pubmed References

  6. Mammalian Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Detection), ELISA - ABIN191349 : Nakaura, Morimoto, Yanaga, Nakata, Nishi, Imaizumi, Ohtsuki: Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy. in The American journal of physiology 1999 (PubMed)
    Show all 6 Pubmed References

  7. Cow (Bovine) Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Detection), ELISA - ABIN191346 : Urasawa, Wada, Machida, Yuasa, Shimatsu, Wakao, Yuasa, Sano, Nonaka, Nakamura, Takeda: Selective vacuolar degeneration in dystrophin-deficient canine Purkinje fibers despite preservation of dystrophin-associated proteins with overexpression of Dp71. in Circulation 2008 (PubMed)
    Show all 6 Pubmed References

  8. Cow (Bovine) Monoclonal Cardiac Troponin T2 Primary Antibody for ELISA (Capture), ELISA - ABIN191348 : van den Berg, Abu-Issa, de Boer, Hutson, de Boer, Soufan, Ruijter, Kirby, van den Hoff, Moorman: A caudal proliferating growth center contributes to both poles of the forming heart tube. in Circulation research 2009 (PubMed)
    Show all 6 Pubmed References

More Antibodies against Cardiac Troponin T2 Interaction Partners

Human Troponin T2, Cardiac (TNNT2) interaction partners

  1. Among patients with chest pain and stable troponin levels, any detectable level of high-sensitivity cardiac troponin is associated with an increased risk of death and cardiovascular disease.

  2. High-sensitivity cTnT measurement increases the detection of perioperative myocardial infarction.

  3. In a heart failure cohort, high sensitivity troponin T serum levels had very significant prognostic value.

  4. Asymptomatic cTnT elevation might be strongly associated with all-cause and cardiovascular mortality in dialysis patients without diabetic nephropathy.

  5. Higher postoperative concentrations of high-sensitivity troponin T are independently associated with all-cause mortality in patients undergoing on-pump cardiac surgery.

  6. variants in TNNT2 and BAG3 (show BAG3 Antibodies) are associated with a high propensity to life-threatening cardiomyopathy presenting from childhood and young adulthood.

  7. Binding of the MBNL (show MBNL1 Antibodies) zinc fingers to cardiac troponin T pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  8. The measurement of high-sensitivity cardiac troponin T plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.

  9. Data suggest that modulation of structural dynamics far from the regulatory Ca2 (show CA2 Antibodies)+-binding site is the underlying molecular mechanism for many TNNC1 (show TNNC1 Antibodies) mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (show TNNI2 Antibodies)(SW)] switch peptide binds to TNNC1 (show TNNC1 Antibodies) and stabilizes the open TNNC1 (show TNNC1 Antibodies) conformation.

  10. Data suggest that the tropomyosin (show TPM2 Antibodies) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2, R92L) that is associated with hypertrophic cardiomyopathy.

Pig (Porcine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC (show PKC Antibodies) phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Rabbit Troponin T2, Cardiac (TNNT2) interaction partners

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Mouse (Murine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. TnTA30V mutation attenuated Ca(2 (show CA2 Antibodies)+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin (show MYH6 Antibodies) heavy chain but augmented these parameters against beta-myosin heavy chain (show MYH7 Antibodies), suggesting divergent contractile phenotypes.

  2. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A (show DYRK1A Antibodies) overexpression.

  3. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT (show TNNI1 Antibodies), Ca(2 (show CA2 Antibodies)+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  4. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain (show MYH7 Antibodies)

  5. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  6. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  7. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  8. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  9. TnT (show TNNI1 Antibodies) mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 (show MYH6 Antibodies) and hypertrophic cardiomyopathy in the presence of MYH7 (show MYH7 Antibodies).

  10. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

Zebrafish Troponin T2, Cardiac (TNNT2) interaction partners

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1 (show TNNI1 Antibodies), Tnnt2, and Tnnt3b were conserved in the central tropomyosin (show TPM2 Antibodies)- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 (show TNNI1 Antibodies) and Tnnt2, but not Tnnt3b.

Cardiac Troponin T2 (TNNT2) Antigen Profile

Protein Summary

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Gene names and symbols associated with TNNT2

  • troponin T type 2 (cardiac) (TNNT2) antibody
  • troponin T2, cardiac (Tnnt2) antibody
  • troponin T type 2 (cardiac) (Tnnt2) antibody
  • troponin T type 2 (cardiac) (tnnt2) antibody
  • troponin T2a, cardiac (tnnt2a) antibody
  • CMH2 antibody
  • CMPD2 antibody
  • CT3 antibody
  • cTnT antibody
  • Ctt antibody
  • CTTG antibody
  • LVNC6 antibody
  • RATCTTG antibody
  • RCM3 antibody
  • tnnt2 antibody
  • Tnnt3 antibody
  • Tnt antibody
  • TnTC antibody

Protein level used designations for TNNT2

troponin T, cardiac muscle , troponin T2, cardiac , cardiac troponin 2 , cardiac troponin T , troponin T type 2, cardiac , cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , Troponin T cardiac , cTnT , cardiac muscle troponin T , cardiac troponin T2 , tnTc , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , Troponin T, cardiac muscle , troponin T cardiac isoform , cardiac TnT , sih , silent heart

GENE ID SPECIES
493940 Felis catus
100379561 Cavia porcellus
403532 Canis lupus familiaris
7139 Homo sapiens
24837 Rattus norvegicus
398518 Xenopus laevis
396433 Gallus gallus
100622450 Sus scrofa
286816 Bos taurus
100009428 Oryctolagus cuniculus
21956 Mus musculus
58071 Danio rerio
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