Troponin T2, Cardiac Proteins (TNNT2)

The protein encoded by TNNT2 is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Additionally we are shipping Cardiac Troponin T2 Antibodies (379) and Cardiac Troponin T2 Kits (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNNT2 7139 P45379
TNNT2 24837 P50753
TNNT2 21956 P50752
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Top Cardiac Troponin T2 Proteins at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$752.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Wild boar His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$784.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,746.33
Details
Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$2,753.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,790.33
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,795.83
Details

TNNT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus) , ,
,
Mouse (Murine)
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More Proteins for Troponin T2, Cardiac (TNNT2) Interaction Partners

Human Troponin T2, Cardiac (TNNT2) interaction partners

  1. Binding of the MBNL (show MBNL1 Proteins) zinc fingers to cardiac troponin T pre-mRNA is specific and relatively simple, unlike the complex multiple dimer-trimer stoichiometries postulated in some previous studies.

  2. The measurement of high-sensitivity cardiac troponin T plasma concentration within large nationally-representative surveys such as the Health Survey for England is feasible.

  3. Data suggest that modulation of structural dynamics far from the regulatory Ca2 (show CA2 Proteins)+-binding site is the underlying molecular mechanism for many TNNC1 (show TNNC1 Proteins) mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (show TNNI2 Proteins)(SW)] switch peptide binds to TNNC1 (show TNNC1 Proteins) and stabilizes the open TNNC1 (show TNNC1 Proteins) conformation.

  4. Data suggest that the tropomyosin (show TPM2 Proteins) overlap region structure and function are affected differentially by a point mutation in cardiac tropomyosin (TPM1, D230N) that is associated with dilated cardiomyopathy as compared to a point mutation in cardiac troponin T (TNNT2, R92L) that is associated with hypertrophic cardiomyopathy.

  5. High T2-weighted signal intensity on cine MRI is associated with elevated troponin T in hypertrophic cardiomyopathy.

  6. The high negative predictive value of preoperative hs-cTnT and NT-proBNP suggest usefulness as a "rule-out" test to confirm low risk of postoperative Myocardial Infarction

  7. Generated is a gene-targeted knock-in murine model of the autosomal dominant Arg141Trp (R141W) mutation in human Tnnt2. Tnnt2 R141W mutation causes a Ca2 (show CA2 Proteins)+ desensitization and mice adapt by increasing Ca2 (show CA2 Proteins)+-transient amplitudes, which impairs Ca2 (show CA2 Proteins)+ handling dynamics, metabolism and responses to beta-adrenergic activation.

  8. A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.

  9. Our study supports that mutations in MYH7 (show MYH7 Proteins) and MYBPC3 (show MYBPC3 Proteins) should be the first focus of moleculargenetic analysis in HCM, and that mutations in TNNT2 have a low prevalence in Brazilian population. All mutations detected were missense mutations, whereas two mutations in MYH7 (show MYH7 Proteins) had not been described before.

  10. Dyrk1A modulates SRp55-promoted cTnT exon 5 inclusion

Pig (Porcine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

Cow (Bovine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. Significant changes in thin filament Ca2 (show CA2 Proteins)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T.

  2. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions.

Rabbit Troponin T2, Cardiac (TNNT2) interaction partners

  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.

  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.

Mouse (Murine) Troponin T2, Cardiac (TNNT2) interaction partners

  1. TnTA30V mutation attenuated Ca(2 (show CA2 Proteins)+)-activated maximal tension and length-mediated cross-bridge recruitment against alpha-myosin (show MYH6 Proteins) heavy chain but augmented these parameters against beta-myosin heavy chain (show MYH7 Proteins), suggesting divergent contractile phenotypes.

  2. The shift from cTnT exon 5 inclusion to exclusion during development was delayed in the heart of Ts65Dn mice due to Dyrk1A (show DYRK1A Proteins) overexpression.

  3. for hypertrophic cardiomyopathy (HCM)-causing mutations in TnT (show TNNI1 Proteins), Ca(2 (show CA2 Proteins)+)-sensitisation together with uncoupling in vitro is the usual response and both factors may contribute to the HCM phenotype

  4. cardiomyopathy mutation (R97L) in mouse cardiac troponin T has an effect on the muscle length-mediated recruitment of crossbridges and is modified divergently by alpha- and beta-myosin heavy chain (show MYH7 Proteins)

  5. Data indicate that high-sensitivity troponin T (hs-TnT) levels are influenced by myocardial dysfunction/heart failure (HF) in acute exacerbation of chronic obstructive lung disease (AECOPD), but provide independent prognostic information.

  6. cTnT elevation emerged as a strong, independent predictor of 30-day mortality and remained a modest, but significant, predictor throughout 2 years post transcatheter aortic valve implantation.

  7. MBPC and troponin-I phosphorylation modulate myofilament length-dependent activation

  8. Data indicate that the troponin T Tnnt2(MerCreMer/+) mouse model also provides a useful tool to trace myocardial lineage during development.

  9. TnT (show TNNI1 Proteins) mutation F72L leads to contractile changes that are linked to dilated cardiomyopathy in the presence of MYH6 (show MYH6 Proteins) and hypertrophic cardiomyopathy in the presence of MYH7 (show MYH7 Proteins).

  10. TNT increases slightly during low flux-hemodialysis. High-flux hemodialysis eliminates the biomarker and can mask increases caused by cardiac disease.

Zebrafish Troponin T2, Cardiac (TNNT2) interaction partners

  1. Data showed that CXCR4a was significantly more highly expressed in tnnt2 knocked down mutant at 48 and 60 hpf than controls.

  2. We show that the zebrafish silent heart (sih) mutation affects the gene tnnt2.

  3. Tnnt1 (show TNNI1 Proteins), Tnnt2, and Tnnt3b were conserved in the central tropomyosin (show TPM2 Proteins)- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 (show TNNI1 Proteins) and Tnnt2, but not Tnnt3b.

Cardiac Troponin T2 (TNNT2) Protein Profile

Protein Summary

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

Gene names and symbols associated with Troponin T2, Cardiac Proteins (TNNT2)

  • troponin T type 2 (cardiac) (TNNT2)
  • troponin T2, cardiac (Tnnt2)
  • troponin T type 2 (cardiac) (Tnnt2)
  • troponin T type 2 (cardiac) (tnnt2)
  • troponin T2a, cardiac (tnnt2a)
  • CMH2 protein
  • CMPD2 protein
  • CT3 protein
  • cTnT protein
  • Ctt protein
  • CTTG protein
  • LVNC6 protein
  • RATCTTG protein
  • RCM3 protein
  • tnnt2 protein
  • Tnnt3 protein
  • Tnt protein
  • TnTC protein

Protein level used designations for Troponin T2, Cardiac Proteins (TNNT2)

troponin T, cardiac muscle , troponin T2, cardiac , cardiac troponin 2 , cardiac troponin T , troponin T type 2, cardiac , cardiomyopathy, dilated 1D (autosomal dominant) , cardiomyopathy, hypertrophic 2 , Troponin T cardiac , cTnT , cardiac muscle troponin T , cardiac troponin T2 , tnTc , cardiac troponin T form I , tnTC , troponin T, cardiac muscle isoforms , Troponin T, cardiac muscle , troponin T cardiac isoform , cardiac TnT , sih , silent heart

GENE ID SPECIES
493940 Felis catus
100379561 Cavia porcellus
403532 Canis lupus familiaris
7139 Homo sapiens
24837 Rattus norvegicus
398518 Xenopus laevis
396433 Gallus gallus
100622450 Sus scrofa
286816 Bos taurus
100009428 Oryctolagus cuniculus
21956 Mus musculus
58071 Danio rerio
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