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TYSND1 encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. Additionally we are shipping Trypsin Domain Containing 1 Proteins (3) and many more products for this protein.
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characterization of protease function and self-cleavage of mouse Tysnd1
The proteolytic activity of oligomeric Tysnd1 is in turn controlled by self-cleavage of Tysnd1 and degradation of Tysnd1 cleavage products by PsLon.
Our data established that peroxisomal processing protease Tysnd1 is necessary to mediate the physiological functions of PTS2-containing substrates.
characterization of function of human TYSND1, including putative regulation by self-cleavage
This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome. The encoded protein is also capable of removing the C-terminal peroxisomal targeting signal (PTS1) from proteins in the peroxisomal matrix. The full-length protein undergoes self-cleavage to produce shorter, potentially inactive, peptides. Alternative splicing results in multiple transcript variants for this gene.
peroxisomal leader peptide-processing protease
, trypsin domain containing 1
, peroxisomal leader peptide-processing protease-like
, trypsin domain-containing protein 1