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Tumor Necrosis Factor-Inducible Protein 6 Proteins (TNFAIP6)

The protein encoded by TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. Additionally we are shipping Tumor Necrosis Factor-Inducible Protein 6 Kits (36) and Tumor Necrosis Factor-Inducible Protein 6 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat TNFAIP6 TNFAIP6 84397  
TNFAIP6 21930 O08859
TNFAIP6 7130 P98066
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Top Tumor Necrosis Factor-Inducible Protein 6 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,669.33
Details

TNFAIP6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Tumor Necrosis Factor-Inducible Protein 6 (TNFAIP6) Interaction Partners

Mouse (Murine) Tumor Necrosis Factor-Inducible Protein 6 (TNFAIP6) interaction partners

  1. Data (including data from studies in knockout mice) suggest that TSG-6 is needed for release of hyaluronan rafts (leukocyte-adhesive rafts) from apical surface of tracheal mucosa into bronchoalveolar lavage fluid as heavy chain hyaluronan complexes.

  2. the well characterized hyaluronan-binding site in the TSG-6 Link module is not used for recognition during transfer of HCs (show HLCS Proteins) onto HA.

  3. Thus, TSG6, HA, and IalphaI were crucial factors for the settlement and probably the subsequent differentiation of MSCs.

  4. BM-MSCs injected into mice with colitis do not localize to the intestine but instead form aggregates in the peritoneum where they produce immunoregulatory molecules, including TSG6, that reduce intestinal inflammation.

  5. This study demonstrated that following stimulation with TNF-alpha (show TNF Proteins), MSCs modulate microglia activity through TSG-6.

  6. suggest that TSG-6 plays an important role in MSCs-mediated immunosuppressive effect on DC

  7. This study provides insight into what we believe to be a previously undescribed multifaceted role of mesenchymal stem cell-released TSG-6 in wound healing.

  8. TSG-6 is implicated in the experimental murine model of allergic pulmonary inflammation and is likely to contribute to the pathogenesis of asthma

  9. TSG-6 increases the accumulation of HA in the cell-associated matrix, partially by preventing its dissolution from the cell-associated matrix into the conditioned medium, but primarily by inducing HA synthesis

  10. analysis of irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor (show TNF Proteins)-stimulated gene-6

Human Tumor Necrosis Factor-Inducible Protein 6 (TNFAIP6) interaction partners

  1. Data postulate that the molecular cross-linking enhanced by the multiple binding modes of the Link module might be critical for remodeling the ECM (show MMRN1 Proteins) during inflammation/ovulation and might contribute to other functions of TSG-6.

  2. the well characterized hyaluronan-binding site in the TSG-6 Link module is not used for recognition during transfer of HCs (show HLCS Proteins) onto HA.

  3. TSG-6 exhibited anti-inflammatory effects during the wound healing process and cicatrization and significantly diminished hypertrophic scar formation in a rabbit ear model

  4. results suggest that systemic administration of hASC (show PYCARD Proteins) or TSG-6 may be novel approaches to reverse CS-induced myelosuppression.

  5. TSG-6 activity in tissues, was examined.

  6. TSG-6 expression by hMSCs was induced 12 h after oropharyngeal delivery to LPS (show IRF6 Proteins)-exposed lungs. Knockdown of TSG-6 expression in hMSCs by RNA interference abrogated most of their anti-inflammatory effects.

  7. Heavy chain transfer by tumor necrosis factor (show TNF Proteins)-stimulated gene 6 to the bikunin (show AMBP Proteins) proteoglycan (show Vcan Proteins).

  8. data suggest that TSG-6 expression might be essential in endometrial matrix organization and feto-maternal communication during the implantation process.

  9. the HA-binding site defined here may not play a role in TSG-6-mediated transfer of heavy chains from inter-alpha-inhibitor onto HA, a process known to be essential for ovulation.

  10. TSG-6 suppresses CXCL8 (show IL8 Proteins)-mediated chemotaxis of neutrophils; this lower potency effect might be important at sites where there is high local expression of TSG-6.

Tumor Necrosis Factor-Inducible Protein 6 (TNFAIP6) Protein Profile

Protein Summary

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.

Gene names and symbols associated with TNFAIP6

  • tumor necrosis factor alpha induced protein 6 (Tnfaip6)
  • tumor necrosis factor, alpha-induced protein 6 (TNFAIP6)
  • Tnfip6 protein
  • TSG-6 protein
  • TSG6 protein

Protein level used designations for TNFAIP6

tumor necrosis factor alpha induced protein 6 , tumor necrosis factor-inducible gene 6 protein , tumor necrosis factor-inducible protein 6 , TNF alpha-induced protein 6 , TNF-stimulated gene 6 protein , tumor necrosis factor alpha-induced protein 6 , tumor necrosis factor induced protein 6 , tumor necrosis factor, alpha-induced protein 6 , hyaluronate-binding protein , tumor necrosis factor alpha-inducible protein 6 , tumor necrosis factor-stimulated gene-6 protein , TSG-6 , hyaluronate-binding protein PS4 , secreted hyaluronate binding protein

GENE ID SPECIES
84397 Rattus norvegicus
424315 Gallus gallus
21930 Mus musculus
7130 Homo sapiens
100009149 Oryctolagus cuniculus
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