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Tumor Protein P63 Proteins (TP63)

TP63 encodes a member of the p53 family of transcription factors. Additionally we are shipping p63 Antibodies (72) and p63 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TP63 21454 P11983
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
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Top p63 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,976.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$310.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

TP63 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Top referenced p63 Proteins

  1. Human p63 Protein expressed in Baculovirus infected Insect Cells - ABIN2005583 : Crum, McKeon: p63 in epithelial survival, germ cell surveillance, and neoplasia. in Annual review of pathology 2010 (PubMed)

  2. Human p63 Protein expressed in Wheat germ - ABIN1323400 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

More Proteins for Tumor Protein P63 (TP63) Interaction Partners

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. IL-6 (show IL6 Proteins)/P-STAT3 (show STAT3 Proteins) activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  2. In vivo inhibition of both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) in combination accelerates tumor regression and increases survival of p53 (show TP53 Proteins)-deficient mice.

  3. Data show that T-complex protein 1 (TCP-1) may be a crucial downstream molecule of purinergic receptor P2X 7 (show P2RX7 Proteins) (P2X7R (show P2RX7 Proteins)) and plays a role in lymphoid neoplasm metastasis.

  4. The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Proteins) and actin mediated via gelsolin (show GSN Proteins), suggesting that CCT (show FLVCR2 Proteins) may influence processes depending on gelsolin (show GSN Proteins) activity, such as cell motility.

  5. p63 (show CKAP4 Proteins) expression could be detected as early as E8.5 in mouse embryos preceding epidermal commitment.

  6. Lack of embryonic brain development was found in p63 (show CKAP4 Proteins)-knockout mice.

  7. Data show that the transcription factor protein (show SSRP1 Proteins) 63 (p63 (show CKAP4 Proteins)) is a master regulator of the transition from the reserve to the active stem cell pool in the epithelium.

  8. Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 (show PVRL4 Proteins) regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)

  9. Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells.

  10. Some miRs control p63 (show CKAP4 Proteins) expression, and p63 (show CKAP4 Proteins) regulates the miR (show MLXIP Proteins) expression profile in the epidermis. p63 (show CKAP4 Proteins) controls miR (show MLXIP Proteins) expression at different levels.

Human Tumor Protein P63 (TP63) interaction partners

  1. DeltaNp63alpha is a vital epithelial-mesenchymal transition repressor in cervical squamous cell carcinoma cells. SCC (show CYP11A1 Proteins) patients with low DeltaNp63alpha expression and high EMT (show ITK Proteins) level show more frequent metastasis and recurrence as well as reduced overall survival. The miR (show MLXIP Proteins)-205/ZEB1 axis is involved in the inhibition effect of DeltaNp63alpha on EMT (show ITK Proteins).

  2. Immunocytochemistry using this antibody cocktail comprises five antibodies recognising p63 (show RPE65 Proteins), and cytokeratins ( 7, 18, 5 and 14) showed good sensitivity and specificity for diagnosing breast cancers. Thus, this method is useful for mammary cytology using FNA

  3. HCC1806 cells endogenously express p63 (show RPE65 Proteins), mainly as the DeltaNp63alpha isoform. Endogenous p63 (show RPE65 Proteins) is required to suppress the expression of luminal markers and maintain the basal epithelial phenotype, but p63 (show RPE65 Proteins) loss is insufficient to induce full luminal-type differentiation. p63 (show RPE65 Proteins) exerts multiple pro-oncogenic effects on cell differentiation, proliferation and adhesion in basal-like breast cancers.

  4. The findings suggest that miR (show MLXIP Proteins)-203 is a tumor suppressor that plays an important role in inhibiting the occurrence of Kazakh esophageal squamous cell carcinoma in China via regulating the expression of p63 (show RPE65 Proteins).

  5. Single-cell pattern is frequently a component of morpheaform basal cell carcinoma. TP63/cytokeratin (show KRT4 Proteins) staining may aid in identification of these tumor cells.

  6. Although preliminary, the expression levels of DeltaNp63 mRNA and miR (show MLXIP Proteins)-203 seem to be promising for cervical cancer screening. In addition, positive correlation between miR (show MLXIP Proteins)-203 and DeltaNp63 expression suggests the possible existence of some indirect pathways

  7. Study shows that DeltaNp63alpha controls YB-1 (show YBX1 Proteins) protein stability suggesting that DeltaNp63alpha/YB-1 (show YBX1 Proteins) cross talk is relevant for survival of basal keratinocytes in stratified epithelia.

  8. results established a cell type-specific function of DeltaNp63alpha in induction of quiescence and downregulation of the BRCA1 pathway which suggested a role of DeltaNp63alpha in the dormancy of luminal breast cancers.

  9. The immunostaining of FNA breast specimens for p63 (show RPE65 Proteins) and CK 34beta-E12 (show ELSPBP1 Proteins) may help in difficult diagnoses

  10. p63 (show RPE65 Proteins) and TCF4 (show TCF4 Proteins) coexist at a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) response elements of MMP7 (show MMP7 Proteins) on the chromatin, where beta-catenin (show CTNNB1 Proteins) recruitment is attenuated.

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. they unravel essential roles of TAp63 and p53 (show TP53 Proteins) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (show NOTCH1 Proteins) signalling and caspase 3 (show CASP3 Proteins) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (show BBC3 Proteins) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (show RPS19 Proteins)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (show TP53 Proteins) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (show BMP4 Proteins).

  3. The role of p63 as a negative Wnt (show WNT2 Proteins)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Protein Profile

Protein Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with Tumor Protein P63 Proteins (TP63)

  • tumor protein p63 (TP63)
  • tumor protein p63 (tp63)
  • tumor protein p63 (LOC100227936)
  • tumor protein p73-like (LOC100393670)
  • tumor protein p73-like (LOC100433100)
  • tumor protein p73-like (LOC100480840)
  • tumor protein p73-like (LOC100496308)
  • tumor protein p73-like (LOC100512967)
  • tumor protein p73-like (LOC100545037)
  • tumor protein p73-like (LOC100577122)
  • tumor protein p73-like (LOC100594205)
  • tumor protein p73-like (LOC100611345)
  • tumor protein p73-like (LOC100624851)
  • tumor protein p73-like (LOC100648488)
  • t-complex protein 1 (Tcp1)
  • transformation related protein 63 (Trp63)
  • tumor protein p63 (Tp63)
  • tumor protein p63-like (LOC100355881)
  • AI462811 protein
  • AI528772 protein
  • AIS protein
  • B(p51A) protein
  • B(p51B) protein
  • c-cpn protein
  • CCT protein
  • Cct1 protein
  • Ccta protein
  • DNp63 protein
  • EEC3 protein
  • id:ibd3516 protein
  • ket protein
  • LMS protein
  • NBP protein
  • np63 protein
  • OFC8 protein
  • p40 protein
  • p51 protein
  • P51/P63 protein
  • p53CP protein
  • P63 protein
  • p73H protein
  • p73L protein
  • RHS protein
  • SHFM4 protein
  • Tcp-1 protein
  • TP53CP protein
  • TP53L protein
  • Tp63 protein
  • tp73l protein
  • tp73l-A protein
  • TRic protein
  • Trp53rp1 protein
  • TRP63 protein
  • wu:fc89f04 protein
  • wu:fk85h07 protein
  • wu:fk88b02 protein
  • Xp63 protein

Protein level used designations for Tumor Protein P63 Proteins (TP63)

tumor protein p63 , tumor protein 63 , p63 gamma , tumor protein p73-like , tumor protein 63-like , CCT-alpha , T-complex protein 1 subunit alpha , T-complex protein 1 subunit alpha A , T-complex protein 1 subunit alpha B , TCP-1-A , TCP-1-B , TCP-1-alpha , t-complex polypeptide 1 , tailless complex polypeptide 1A , tailless complex polypeptide 1B , transformation-related protein 63 , CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , transformation related protein 63 , tumor protein 63 kDa , delta-Np63 , fc89f04

GENE ID SPECIES
100059752 Equus caballus
100170632 Oryzias latipes
703997 Macaca mulatta
100048992 Ovis aries
460930 Pan troglodytes
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100393670 Callithrix jacchus
100433100 Pongo abelii
100444448 Pongo abelii
100480840 Ailuropoda melanoleuca
100496308 Xenopus (Silurana) tropicalis
100512967 Sus scrofa
100545037 Meleagris gallopavo
100577122 Apis mellifera
100594205 Nomascus leucogenys
100606847 Nomascus leucogenys
100611345 Pan troglodytes
100624851 Sus scrofa
100648488 Bombus terrestris
21454 Mus musculus
22061 Mus musculus
8626 Homo sapiens
246334 Rattus norvegicus
260407 Danio rerio
373640 Xenopus laevis
374269 Gallus gallus
100732143 Cavia porcellus
100625258 Sus scrofa
488125 Canis lupus familiaris
615335 Bos taurus
101108874 Ovis aries
100355881 Oryctolagus cuniculus
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