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U2AF1 belongs to the splicing factor SR family of genes. Additionally we are shipping U2AF1 Antibodies (47) and many more products for this protein.
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The U2AF35(S34F) mutation alters interaction with CFIm59 (show CPSF7 Proteins), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 (show ATG7 Proteins) pre-mRNA, decreasing levels of ATG7 (show ATG7 Proteins) protein and defective autophagy, ultimately leading to transformation.
data support the impact of genes from the Abcg1 (show ABCG1 Proteins)-U2af1 region as modifiers of Tc1 (show C8orf4 Proteins)-dependent memory and locomotor phenotypes in Tc1 (show C8orf4 Proteins) mouse model of Down syndrome.
findings support the hypothesis that mutant U2AF1 alters downstream gene isoform expression, thereby contributing to abnormal hematopoiesis in patients with MDS (show MECOM Proteins)
this study establishes definitely the contribution of the Abcg1 (show ABCG1 Proteins)-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memory.
infer that U2AF1 S34 mutations characterize a distinct subgroup of myelodysplastic syndrome
Alternative splicing of U2AF1 reveals a shared repression mechanism for duplicated exons controlled by SRF3.
Our results provide mechanistic explanations of the magnitude of splicing changes observed in U2AF1-mutant cells and why tumors harboring U2AF1 mutations always retain an expressed copy of the wild-type allele
Mutations in ASXL1 (show ASXL1 Proteins), U2AF1, and SF3B1 (show SF3B2 Proteins) are common in Chinese patients with myelodysplastic syndromes.
in primary myelofibrosis, anemia was significantly associated with U2AF1 mutation; study confirms previous observation regarding the association of mutant U2AF1 with anemia supporting its role in hematopoiesis and in the pathogenesis of PMF (show PRB1 Proteins)-associated anemia
In multivariate analysis, U2AF1 and TP53 (show TP53 Proteins) mutations retained independent prognostic significance across 93 cases of acute myeloid leukemia (show BCL11A Proteins)
The mutational status of the SRSF2 (show SRSF2 Proteins), U2AF1 and ZRSR2 (show ZRSR2 Proteins) did not affect the response rate or survival in MDS (show PAFAH1B1 Proteins) patients who had received first-line decitabine treatment.
A mutant U2AF1 (S34F) found in a variety of cancer types results in delayed splicing and disruption of kinetic competition during transcription.
The S34F mutation alters U2AF1 function in the context of specific RNA sequences, leading to aberrant alternative splicing of target genes, some of which may be relevant for myelodysplastic syndromes pathogenesis.
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
U2 small nuclear RNA auxiliary factor 1
, RNA recognition motif-containing protein RRM
, RNA-binding region RNP-1 domain-containing protein
, U2 snRNP auxiliary factor small subunit
, U2(RNU2) small nuclear RNA auxiliary factor 1
, U2 auxiliary factor 35 kDa subunit
, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF),35 kDa
, splicing factor U2AF 35 kDa subunit
, U2 small nuclear RNA auxillary factor 1
, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
, U2(RNU2) small nuclear RNA auxiliary factor binding protein
, splicing factor U2AF 35kDa subunit
, U2snRNP auxiliary factor small subunit
, uncharacterized protein LOC687575
, U2(RNU2) small nuclear RNA auxillary factor 1