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Ubiquitin Associated and SH3 Domain Containing, A Proteins (UBASH3A)

UBASH3A encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Additionally we are shipping Ubiquitin Associated and SH3 Domain Containing, A Antibodies (75) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBASH3A 53347 P57075
Mouse UBASH3A UBASH3A 328795 Q3V3E1
Rat UBASH3A UBASH3A 309666  
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Top Ubiquitin Associated and SH3 Domain Containing, A Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

UBASH3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Interaction Partners

Human Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) interaction partners

  1. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus.

  2. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease.

  3. Addition of PTPN22 (show PTPN22 Proteins) and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction.

  4. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases.

  5. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype

  6. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK (show EPHA3 Proteins) 293 cells.

  7. Sts-1 (show STS1 Proteins) and Sts-2 bind to Cbl (show CBL Proteins) and inhibit endocytosis of receptor tyrosine kinases

  8. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin (show DNM1 Proteins) via the SH3 domain of TULA binding proline-rich sequences in dynamin (show DNM1 Proteins)

  9. TULA enhances the apoptotic effect of AIF (show AIFM1 Proteins) by facilitating the interactions of AIF (show AIFM1 Proteins) with its apoptotic co-factors

  10. Binds to ABCE-1 (show ABCE1 Proteins) and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events.

Mouse (Murine) Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) interaction partners

  1. Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.

  2. The lack of TULA facilitates T-cell responses to TCR/CD3 (show CD3E Proteins) stimulation, thus exacerbating T-cell-dependent inflammation.

  3. Skeletal analysis of mice that do not express TULA or TULA-2 (show STS1 Proteins) proteins (DKO mice) revealed that there was a decrease in bone volume due to increased osteoclast numbers and function.

  4. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 (show ZAP70 Proteins) and T cell receptor signaling pathways.

  5. Sts-2(phosphoglycerate mutase) adopts the conformation of an active phosphatase whose activity is fundamentally different from that of Sts-1 (show STS1 Proteins) despite the strong structural homology.

  6. the crystal structure of Sts-2(PGM (show Vcan Proteins)) in the phosphorylated active form and bound to VO(3)

  7. The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.

Ubiquitin Associated and SH3 Domain Containing, A (UBASH3A) Protein Profile

Protein Summary

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with UBASH3A

  • ubiquitin associated and SH3 domain containing, A (UBASH3A)
  • ubiquitin associated and SH3 domain containing A (UBASH3A)
  • ubiquitin associated and SH3 domain containing, A (Ubash3a)
  • 5830413C03Rik protein
  • C330001M22 protein
  • CLIP4 protein
  • Sts-2 protein
  • TULA protein
  • TULA-1 protein
  • UBASH3A protein

Protein level used designations for UBASH3A

ubiquitin associated and SH3 domain containing, A , T-cell ubiquitin ligand 1 , T-cell ubiquitin ligand protein , cbl-interacting protein 4 , suppressor of T-cell receptor signaling 2 , ubiquitin-associated and SH3 domain-containing protein A

GENE ID SPECIES
418535 Gallus gallus
474125 Pan troglodytes
53347 Homo sapiens
487779 Canis lupus familiaris
514555 Bos taurus
328795 Mus musculus
309666 Rattus norvegicus
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