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USP20 encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. Additionally we are shipping USP20 Proteins (4) and many more products for this protein.
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Human Polyclonal USP20 Primary Antibody for WB - ABIN658416
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Human Polyclonal USP20 Primary Antibody for IHC (p), IHC - ABIN249927
Curcio-Morelli, Zavacki, Christofollete, Gereben, de Freitas, Harney, Li, Wu, Bianco: Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. in The Journal of clinical investigation 2003
we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2.
findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis
data establish a new function of USP20 in genome maintenance and DNA repair.
Analysis of indel variations in the human disease-associated genes CDKN2AIP (show CDKN2AIP Antibodies), WDR66 (show WDR66 Antibodies), USP20 and OR7C2 (show OR7C2 Antibodies) in a Korean population.
Our results point to USP20 as a key negative regulator of HTLV-1 Tax (show CNTN2 Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) signaling.
identification and description of VDU2 in human cells
von Hippel-Lindau protein (show VHLL Antibodies)-interacting deubiquitinating enzyme 2 (show USP2 Antibodies) (VDU2) deubiquitinates and stabilizes HIF-1alpha (show HIF1A Antibodies).
that pro- and anti-inflammatory activities of beta-arrestin2 (show ARRB2 Antibodies) are determined by beta-arrestin2 (show ARRB2 Antibodies) ubiquitination and that changes in USP20 expression and/or activity can therefore regulate inflammatory responses
This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
universal stress protein
, ubiquitin specific peptidase 20
, ubiquitin specific protease 20
, Deubiquitinating enzyme 20
, Ubiquitin thioesterase 20
, Ubiquitin-specific-processing protease 20
, ubiquitin carboxyl-terminal hydrolase 20
, ubiquitin thiolesterase 20
, deubiquitinating enzyme 20
, pVHL-interacting deubiquitinating enzyme 2
, ubiquitin thioesterase 20
, ubiquitin-specific-processing protease 20
, VHL-interacting deubiquitinating enzyme 2