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Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Additionally we are shipping USP25 Proteins (4) and many more products for this protein.
Showing 10 out of 61 products:
Human Monoclonal USP25 Primary Antibody for WB - ABIN1882057
Groet, Ives, Jones, Danton, Flomen, Sheer, Hrascan, Pavelic, Nizetic: Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. in Genes, chromosomes & cancer 2000
Show all 3 Pubmed References
Mouse (Murine) Polyclonal USP25 Primary Antibody for WB - ABIN3021998
Zhong, Wang, Fang, Zhang, Luo, Shang, Ouyang, Ouyang, Chen, Xiao: Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. in PLoS ONE 2013
USP25 directly interacted with tankyrases to promote their deubiquitination and stabilization and demonstrated that USP25 deficiency could promote the degradation of tankyrases and consequent stabilization of Axin (show AXIN1 Antibodies) to antagonize Wnt (show WNT2 Antibodies) signaling
Results suggest inhibition of Usp25's catalytic activity upon the non-covalent binding of SUMO2 to the Usp25 SUMO-interacting motif, and found that SUMO2 can competitively block the interaction between the Usp25 ubiquitin-binding region and its ubiquitin substrates.
We detected SNPs at USP25 with associations of genome-wide significance for Inflammatory Bowel Disease.
REM (show REM1 Antibodies) Sleep Behavior Disorder patients with homozygous USP25 rs2823357 progressed to synucleinopathies faster than others.
Findings suggest that ubiquitin-specific protease 25 (USP25) as a VRK2 (show VRK2 Antibodies) substrate that acts on TRiC (show MARVELD2 Antibodies) deubiquitination.
These findings indicate that miR (show MLXIP Antibodies)-200c exerts tumor-suppressive effects for NSCLC through the suppression of USP25 expression and suggests a new therapeutic application of miR (show MLXIP Antibodies)-200c in the treatment of NSCLC.
USP25 is a novel deubiquitinating enzyme negatively regulating virus-induced interferon-beta (show IFNB1 Antibodies) production.
a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1 (show SYVN1 Antibodies), rescuing them from degradation by the proteasome.
Studies indicate that DUBs recycle ubiquitin by processing polyubiquitin chains to generate free ubiquitin, and can be regulated by ubiquitination or phosphorylation.
the second SH2 domain of SYK (show SYK Antibodies) physically interacts with a tyrosine-rich, C-terminal region of USP25 independently of tyrosine phosphorylation
IRF7 (show IRF7 Antibodies) directly binds to the two conserved IRF (show TRIM63 Antibodies) binding sites on the USP25 promoter to drive transcription of Usp25.
Data show that the degradation of TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Antibodies)) and TNF (show TNF Antibodies) receptor-associated Ffactor 6 (TRAF6 (show TRAF6 Antibodies)) was accelerated in ubiquitin-specific protease 25 knockout (USP25-/-) cells after viral infection.
inhibiting the degradation of TRAF3 (show TRAF3 Antibodies) during TLR4 (show TLR4 Antibodies) activation, USP25 enables a balanced innate immune response.
USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17 (show IL17A Antibodies)-triggered signaling.
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999
ubiquitin specific peptidase 25
, ubiquitin carboxyl-terminal hydrolase 25-like
, universal stress protein
, ubiquitin carboxyl-terminal hydrolase 25
, ubiquitin specific protease 25
, USP on chromosome 21
, deubiquitinating enzyme 25
, ubiquitin thioesterase 25
, ubiquitin thiolesterase 25
, ubiquitin-specific processing protease 25
, ubiquitin-specific-processing protease 25