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Ubiquitin Specific Peptidase 28 Proteins (USP28)

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Additionally we are shipping USP28 Antibodies (77) and USP28 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
USP28 57646 Q96RU2
Mouse USP28 USP28 235323 Q5I043
Rat USP28 USP28 315639 D3ZJ96
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Top USP28 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Sf-21 Cells Human His tag   100 μg Log in to see 5 to 8 Days
$523.95
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

USP28 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,

More Proteins for Ubiquitin Specific Peptidase 28 (USP28) Interaction Partners

Human Ubiquitin Specific Peptidase 28 (USP28) interaction partners

  1. These results showed that USP28 is overexpressed in human glioblastomas and it contributes to glioma tumorigenicity.

  2. Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR (show MLXIP Proteins)-4295.

  3. findings provide a first insight into understanding how the enzymatic activity of Usp28 is regulated by its non-catalytic UBR and endogenous ligands.

  4. Dual regulation of Fbw7 (show FBXW7 Proteins) activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 (show FBXW7 Proteins) substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  5. identified Usp28 as a c-MYC (show MYC Proteins) target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC (show MYC Proteins) form a positive feedback loop that maintains high c-MYC (show MYC Proteins) protein levels in tumors

  6. USP28 has a chain preference activity for Lys (show LYZ Proteins)(11), Lys (show LYZ Proteins)(48), and Lys (show LYZ Proteins)(63) diubiquitin (show UBD Proteins) linkages

  7. Usp28 expression was indentified as a independent predictors of survival (P = 0.001) and potentially valuable in prognostic evaluation of bladder cancer

  8. Study reveals a critical mechanism underlying the epigenetic regulation by USP28.

  9. USP28 is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization.

  10. USP28 gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

Mouse (Murine) Ubiquitin Specific Peptidase 28 (USP28) interaction partners

  1. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 (show FBXW7 Proteins) and Usp28, modulate intestinal homeostasis and cancer.

  2. Dual regulation of Fbw7 (show FBXW7 Proteins) activity by Usp28 is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 (show FBXW7 Proteins) substrates, which is equivalently disrupted by loss or overexpression of Usp28.

  3. identified Usp28 as a c-MYC (show MYC Proteins) target gene highly expressed in colorectal cancers, which indicates that USP28 and c-MYC (show MYC Proteins) form a positive feedback loop that maintains high c-MYC (show MYC Proteins) protein levels in tumors

USP28 Protein Profile

Protein Summary

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).

Gene names and symbols associated with USP28

  • ubiquitin specific peptidase 28 (USP28)
  • ubiquitin specific peptidase 28 (usp28)
  • ubiquitin specific protease 28 (LOC100232055)
  • ubiquitin specific protease 28 (LOC100346849)
  • ubiquitin specific peptidase 28 (Usp28)
  • 9830148O20Rik protein
  • AU022237 protein
  • im:7138195 protein
  • mKIAA1515 protein
  • USP28 protein

Protein level used designations for USP28

ubiquitin specific peptidase 28 , ubiquitin carboxyl-terminal hydrolase 28-like , ubiquitin specific protease 28 , ubiquitin carboxyl-terminal hydrolase 28 , deubiquitinating enzyme 28 , ubiquitin carboxyl-terminal hydrolase 28 variant 1 , ubiquitin thioesterase 28 , ubiquitin thiolesterase 28 , ubiquitin-specific-processing protease 28

GENE ID SPECIES
100032176 Monodelphis domestica
100402269 Callithrix jacchus
100468031 Ailuropoda melanoleuca
100492386 Xenopus (Silurana) tropicalis
567050 Danio rerio
696672 Macaca mulatta
100232055 Taeniopygia guttata
100346849 Oryctolagus cuniculus
100558297 Anolis carolinensis
100591669 Nomascus leucogenys
508902 Bos taurus
57646 Homo sapiens
235323 Mus musculus
489400 Canis lupus familiaris
100519614 Sus scrofa
315639 Rattus norvegicus
428246 Gallus gallus
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