Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) Proteins (USP7)

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Additionally we are shipping USP7 Antibodies (161) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse USP7 USP7 252870 Q6A4J8
USP7 7874 Q93009
Rat USP7 USP7 360471 Q4VSI4
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Top USP7 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag SDS-PAGE 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 20 to 21 Days
$140.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
$277.20
Details
HOST_Insect cells (Sf21) Human His tag   25 μg Log in to see 5 to 8 Days
$568.05
Details

USP7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,

More Proteins for Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) Interaction Partners

Fruit Fly (Drosophila melanogaster) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. reveal a conserved mechanism by which Ci/Gli (show GLI1 Proteins) is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers

  2. Genetic and gene expression analyses suggested that GMPS (show GMPS Proteins)/USP7 acts as a transcriptional corepressor

  3. GMP synthetase (show GMPS Proteins) stimulates histone H2B deubiquitylation by the epigenetic silencer USP7

Mouse (Murine) Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. EPOP (E130012A19Rik) interacts with elongin B (show TCEB2 Proteins), elongin C (show TCEB1 Proteins), and USP7 to modulate the chromatin landscape.

  2. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  3. Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Proteins) function in neuroblastoma (show ARHGEF16 Proteins) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Proteins)-amplified tumors.

  4. The present study identified USP7 and TDP-43 (show TARDBP Proteins) as the regulators of CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins), underscoring the significance of the stability control process of CRY (show CRY2 Proteins) proteins for period determination in the mammalian circadian clockwork.

  5. demonstrate that genotoxic stress stimulates Cry1 (show CRY1 Proteins) phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 (show CRY1 Proteins) and shifting circadian clock time

  6. Our results demonstrate that the SCML2 (show SCML2 Proteins)/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis

  7. USP7-mediated mono-deubiquitination of FoxO1 (show FOXO1 Proteins) results in suppression of FoxO1 (show FOXO1 Proteins) transcriptional activity through decreased FoxO1 (show FOXO1 Proteins) occupancy on the promoters of gluconeogenic genes.

  8. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60 (show KAT5 Proteins).

  9. The ubiquitination-deubiquitination cascade mediated by the TRIM27 (show RFP Proteins)-USP7 complex plays an important role in TNF-alpha (show TNF Proteins)-induced apoptosis.

  10. the stability and activity of PPARgamma2 (show PPARG Proteins) are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.

Human Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7) interaction partners

  1. Data suggest that SIRT7 (show SIRT7 Proteins) undergoes Lys (show LYZ Proteins)-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7 (show SIRT7 Proteins); USP7 and SIRT7 (show SIRT7 Proteins) regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC (show G6PC Proteins)); SIRT7 (show SIRT7 Proteins) targets G6PC (show G6PC Proteins) promoter through ELK4 (show ELK4 Proteins). (SIRT7 (show SIRT7 Proteins) = sirtuin 7 (show SIRT7 Proteins); USP7 = ubiquitin specific peptidase 7; G6PC (show G6PC Proteins) = glucose-6-phosphatase catalytic subunit (show G6PC Proteins); ELK4 (show ELK4 Proteins) = transcription factor ELK4 (show ELK4 Proteins))

  2. USP7 is overexpressed and regulates homologous recombination repair in chronic lymphocytic leukemia cells.

  3. Findings demonstrate a crucial role of HAUSP in regulating N-Myc (show MYCN Proteins) function in neuroblastoma (show ARHGEF16 Proteins) in vivo and suggest that HAUSP inhibition is a potential therapy for MYCN (show MYCN Proteins)-amplified tumors.

  4. findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh (show SHH Proteins) pathway, and is a putative therapeutic target for MBs (show PPP1R12A Proteins)

  5. Data suggest that HIV-1 (human immunodeficiency virus type 1) Tat (show TAT Proteins) gene product is stabilized by host cell deubiquitinase USP7, leading to enhanced viral production; HIV-1 in turn up-regulates the USP7 protein expression in human T-lymphocytes.

  6. modulatory role for Trip12 in the USP7-dependent DNA damage response

  7. WDR79 (show WRAP53 Proteins) colocalized and interacted with USP7 in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 (show MDM2 Proteins) and p53 (show TP53 Proteins), thereby increasing the stability and extending the half-life of the two proteins.

  8. USP7 and MARCH7 are involved in the progression of Epithelial ovarian cancer.

  9. The present study identified USP7 and TDP-43 (show TARDBP Proteins) as the regulators of CRY1 (show CRY1 Proteins) and CRY2 (show CRY2 Proteins), underscoring the significance of the stability control process of CRY (show CRY2 Proteins) proteins for period determination in the mammalian circadian clockwork.

  10. We also uncovered the suppression of the p53 (show TP53 Proteins) signaling pathway that mediated the activity of USP7 and LSD1 (show KDM1A Proteins). Furthermore, USP7 and LSD1 (show KDM1A Proteins) expression levels were higher in the 150 glioma patients than these levels in normal brain tissues and were correlated with glioma progression.

USP7 Protein Profile

Protein Summary

Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6 (By similarity).

Gene names and symbols associated with USP7

  • ubiquitin-specific protease 7 (Usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (USP7)
  • ubiquitin specific peptidase 7 (Usp7)
  • ubiquitin specific peptidase 7 (herpes virus-associated) (Usp7)
  • 2210010O09Rik protein
  • AA409944 protein
  • AA617399 protein
  • AU019296 protein
  • AW548146 protein
  • C80752 protein
  • CG1490 protein
  • Dmel\\CG1490 protein
  • HAUSP protein
  • TEF1 protein
  • UBP protein
  • USP7 protein

Protein level used designations for USP7

CG1490-PB , Usp7-PB , ubiquitin specific peptidase 7 (herpes virus-associated) , ubiquitin carboxyl-terminal hydrolase 7-like , deubiquitinating enzyme 7 , herpesvirus-associated ubiquitin-specific protease , mHAUSP , ubiquitin carboxyl-terminal hydrolase 7 , ubiquitin specific protease 7 , ubiquitin thioesterase 7 , ubiquitin thiolesterase 7 , ubiquitin-specific-processing protease 7 , Herpes virus-associated ubiquitin-specific protease , ubiquitin specific protease 7 (herpes virus-associated) , herpes-virus-associated ubiquitin-specific protease , rHAUSP , ubiquitin-specific peptidase 7

GENE ID SPECIES
32169 Drosophila melanogaster
100201254 Hydra magnipapillata
100468835 Ailuropoda melanoleuca
252870 Mus musculus
7874 Homo sapiens
360471 Rattus norvegicus
395126 Gallus gallus
479854 Canis lupus familiaris
100190899 Sus scrofa
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