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UBE2S encodes a member of the ubiquitin-conjugating enzyme family. Additionally we are shipping UBE2S Antibodies (150) and many more products for this protein.
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High UBE2S expression is associated with drug resistance in glioblastoma.
RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
UBE2S is highly expressed in breast cancer
The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C (show UBE2C Proteins), UBE2S, and UBE2D.
Study identified APC (show APC Proteins)/C substrates, including the kinase Nek2A (show NEK2 Proteins), that require Ube2S for degradation. The reconstitution of Nek2A (show NEK2 Proteins)-ubiquitylation revealed that Ube2S does not simply extend a conjugate but instead branches multiple K11-linked chains off the assemblies produced by Ube2C (show UBE2C Proteins).
E2-EPF is overexpressed in cervical cancer and associates with tumor growth
These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1 (show HIF1A Proteins)-mediated regulation of E2-EPF in papillary renal cell carcinoma (show MOK Proteins).
Linkage-specific ubiquitin chain formation by Ube2S is the result of substrate-assisted catalysis.
K11 specificity is determined by an E2 enzyme, UBE2S/E2-EPF, that elongates ubiquitin chains after the substrates are pre-ubiquitinated by UbcH10 (show UBE2C Proteins) or UbcH5 (show UBE2D1 Proteins).
Besides its role in fine-tuning the precise level of Sox2 (show SOX2 Proteins), Ube2s reinforces the self-renewing and pluripotent state of embryonic stem cells.
alongside their canonical function in protein degradation, Ube2C (show UBE2C Proteins) and -S also control the extrusion of the first polar body.
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.
ubiquitin-conjugating enzyme E2S
, ubiquitin-conjugating enzyme E2 S
, ubiquitin-conjugating enzyme e2S
, ubiquitin carrier protein S
, ubiquitin-conjugating enzyme E2-24 kD
, ubiquitin-conjugating enzyme E2-24 kDa
, ubiquitin-conjugating enzyme E2-EPF5
, ubiquitin-protein ligase S
, ubiquitin carrier protein
, Ubiquitin carrier protein S-B
, Ubiquitin-protein ligase S-B
, ubiquitin-conjugating enzyme E2 S-B
, ubiquitin-conjugating enzyme E2S, gene 1