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Ubiquitin-Like Modifier Activating Enzyme 3 Proteins (UBA3)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBA3 Antibodies (34) and UBA3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
UBA3 9039 Q8TBC4
Mouse UBA3 UBA3 22200 Q8C878
UBA3 117553 Q99MI7
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Top UBA3 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,794.00
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$3,201.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,296.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,300.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$443.33
Details

UBA3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus)

Top referenced UBA3 Proteins

  1. Human UBA3 Protein expressed in Escherichia coli (E. coli) - ABIN667686 : Bohnsack, Haas: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN667686

More Proteins for Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) Interaction Partners

Human Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) interaction partners

  1. The study demonstrated that two mutations in UBA3 which were not previously reported confer MLN4924 resistance to MLN4924, a selective NEDD8 (show NEDD8 Proteins)-activating enzyme inhibitor.

  2. E1 (NAE1 (show NAE1 Proteins) and UBA3) and E2 (UBC12 (show ube2m Proteins)) enzymes, as well as global NEDD8 (show NEDD8 Proteins) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma

  3. Report role for neddylation via Nedd8 (show NEDD8 Proteins)-activating enzyme in the regulation of tumor angiogenesis.

  4. Demonstrated that Uba3-betaGD is an independently folded domain in solution and that residues involved in E2 binding are absent from the NMR spectrum, indicating that the E2-binding surface on Uba3-betaGD interconverts between multiple conformations.

  5. structure and mutational analysis of human APPBP1 (show NAE1 Proteins)-UBA3, the heterodimeric E1 enzyme (show ENOPH1 Proteins) for NEDD8 (show NEDD8 Proteins)

  6. Conservation in the mechanism of Nedd8 (show NEDD8 Proteins) activation by the human AppBp1 (show NAE1 Proteins)-Uba3 heterodimer.

  7. Data report the structure of the quaternary complex between human APPBP1 (show NAE1 Proteins)-UBA3, a heterodimeric E1, its ubl NEDD8 (show NEDD8 Proteins), and ATP.

  8. crystal structure of a complex between the C-terminal domain from NEDD8 (show NEDD8 Proteins)'s heterodimeric E1 (APPBP1 (show NAE1 Proteins)-UBA3) and the catalytic core domain of NEDD8 (show NEDD8 Proteins)'s E2 (Ubc12 (show ube2m Proteins))

  9. X-ray crystallographic analysis of APPBP1 (show NAE1 Proteins)-UBA3-NEDD8 (show NEDD8 Proteins) shows that APPBP1 (show NAE1 Proteins)-UBA3's preference for NEDD8 (show NEDD8 Proteins)'s Ala72 appears to be indirect, due to proper positioning of UBA3's Arg190.

UBA3 Protein Profile

Protein Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene names and symbols associated with UBA3

  • ubiquitin-like modifier activating enzyme 3 (UBA3)
  • ubiquitin-like modifier activating enzyme 3 (uba3)
  • ubiquitin-like modifier activating enzyme 3 (Uba3)
  • A830034N06Rik protein
  • AI256736 protein
  • AI848246 protein
  • AW546539 protein
  • hUBA3 protein
  • ube1c protein
  • wu:fb75e04 protein
  • wu:fc37b11 protein
  • zgc:55528 protein

Protein level used designations for UBA3

ubiquitin-like modifier activating enzyme 3 , NEDD8-activating enzyme E1 catalytic subunit , NEDD8-activating enzyme E1 catalytic subunit-like , NEDD8-activating enzyme E1C , Nedd8-activating enzyme hUba3 , UBA3, ubiquitin-activating enzyme E1 homolog , ubiquitin-activating enzyme 3 , ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) , ubiquitin-activating enzyme E1C (homologous to yeast UBA3) , ubiquitin-like modifier-activating enzyme 3 , ubiquitin activating enzyme 3 , ubiquitin-activating enzyme E1C

GENE ID SPECIES
100011849 Monodelphis domestica
100196693 Salmo salar
100392131 Callithrix jacchus
100550920 Meleagris gallopavo
100566540 Anolis carolinensis
9039 Homo sapiens
22200 Mus musculus
406776 Danio rerio
734782 Xenopus laevis
426073 Gallus gallus
476560 Canis lupus familiaris
512647 Bos taurus
117553 Rattus norvegicus
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