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UBE2S encodes a member of the ubiquitin-conjugating enzyme family. Additionally we are shipping UBE2S Proteins (22) and many more products for this protein.
Showing 10 out of 152 products:
Human Polyclonal UBE2S Primary Antibody for WB - ABIN1881968
Wu, Merbl, Huo, Gallop, Tzur, Kirschner: UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 5 references for ABIN1881968
Human Monoclonal UBE2S Primary Antibody for EIA, IF - ABIN452460
Ye, Rape: Building ubiquitin chains: E2 enzymes at work. in Nature reviews. Molecular cell biology 2009
Show all 2 references for ABIN452460
Human Polyclonal UBE2S Primary Antibody for EIA, IHC (p) - ABIN4620549
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 2 references for ABIN4620549
Human Polyclonal UBE2S Primary Antibody for EIA, IHC (p) - ABIN4620550
Liu, Diaz, Haas, Giudice et al.: cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this ... in The Journal of biological chemistry 1992
Show all 2 references for ABIN4620550
Cow (Bovine) Polyclonal UBE2S Primary Antibody for WB - ABIN2774717
Marques, Dupanloup, Vinckenbosch, Reymond, Kaessmann: Emergence of young human genes after a burst of retroposition in primates. in PLoS biology 2005
UBE2S is highly expressed in breast cancer
The anaphase-promoting complex/cyclosome C activity in human cells is tuned by the combinatorial use of three E2 ubiquitin-conjugating enzymes, namely UBE2C (show UBE2C Antibodies), UBE2S, and UBE2D.
Study identified APC (show APC Antibodies)/C substrates, including the kinase Nek2A (show NEK2 Antibodies), that require Ube2S for degradation. The reconstitution of Nek2A (show NEK2 Antibodies)-ubiquitylation revealed that Ube2S does not simply extend a conjugate but instead branches multiple K11-linked chains off the assemblies produced by Ube2C (show UBE2C Antibodies).
E2-EPF is overexpressed in cervical cancer and associates with tumor growth
These findings reveal deregulation of the oxygen-sensing pathway impinging on the positive feedback mechanism of HIF1 (show HIF1A Antibodies)-mediated regulation of E2-EPF in papillary renal cell carcinoma (show MOK Antibodies).
Linkage-specific ubiquitin chain formation by Ube2S is the result of substrate-assisted catalysis.
K11 specificity is determined by an E2 enzyme, UBE2S/E2-EPF, that elongates ubiquitin chains after the substrates are pre-ubiquitinated by UbcH10 (show UBE2C Antibodies) or UbcH5 (show UBE2D1 Antibodies).
E2-EPF UCP (show UCP1 Antibodies) expression induced by growth factors or serum increased HIF-1alpha (show HIF1A Antibodies) protein level under non-hypoxic conditions, suggesting that the Egr-1 (show EGR1 Antibodies)/SRF-UCP (show UCP1 Antibodies)-VHL (show VHL Antibodies) pathway is in part responsible for the increased HIF-1alpha (show HIF1A Antibodies) protein level
Results suggest that UCP (show UCP1 Antibodies) was significantly associated with poor prognosis of esophageal cancer and may be a new molecular target for therapeutic intervention for esophageal squamous cell carcinoma.
UBE2S functions with the APC (show APC Antibodies)/C in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC (show ADCY10 Antibodies) activation, providing a new model for APC (show APC Antibodies)/C function in human cells
Besides its role in fine-tuning the precise level of Sox2 (show SOX2 Antibodies), Ube2s reinforces the self-renewing and pluripotent state of embryonic stem cells.
alongside their canonical function in protein degradation, Ube2C (show UBE2C Antibodies) and -S also control the extrusion of the first polar body.
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.
ubiquitin-conjugating enzyme E2S
, ubiquitin-conjugating enzyme E2 S
, ubiquitin-conjugating enzyme e2S
, ubiquitin carrier protein S
, ubiquitin-conjugating enzyme E2-24 kD
, ubiquitin-conjugating enzyme E2-24 kDa
, ubiquitin-conjugating enzyme E2-EPF5
, ubiquitin-protein ligase S
, ubiquitin carrier protein
, Ubiquitin carrier protein S-B
, Ubiquitin-protein ligase S-B
, ubiquitin-conjugating enzyme E2 S-B
, ubiquitin-conjugating enzyme E2S, gene 1