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The protein encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. Additionally we are shipping UBA1 Antibodies (86) and UBA1 Kits (11) and many more products for this protein.
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recent findings put UBA1 at the center of cellular homeostasis and neurodegeneration [review]
A ubiquitin shuttle DC-UbP reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 (show USP5 Proteins) enzymes.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 (show UBD Proteins) targets it for proteasomal degradation
Ubiquitin-activating enzyme is necessary for 17beta-estradiol-induced breast cancer cell proliferation and migration.
Diminished ubiquitylation phenotype observed in enteropathogenic Escherichia coli infected cells corresponds to a strong reduction in the abundance of both Ube1 and Uba6 (show UBA6 Proteins).
Decrease in free ubiquitin levels under stress allows NEDD8 (show NEDD8 Proteins) to be conjugated through Ube1.
UBA1 knockdown impairs formation of ubiquitin conjugates at DNA double-strand breaks.
Data show that largazole and ester/keto analogs inhibit ubiquitin E1 activation.
Ubiquitin and UBE1 are upregulated in tic epilepsy.
In conclusion, nUBE1L is a novel human E1 like gene highly expressed in adult testis, which plays key role in ubiquitin system, and accordingly influences spermatogenesis and male fertility.
Inhibition of ubiquitin-activating enzyme E1 (Ube1) increases the levels of high- molecular weight mouse Htt (show HTT Proteins) in relatively unaffected tissues, declining in the nuclear fraction with age.
Dysregulation of UBA1 and subsequent ubiquitination pathways led to beta-catenin (show CTNNB1 Proteins) accumulation in a model of spinal muscular atrophy.
These data suggest that Cys (show DNAJC5 Proteins)-278 can affect Ub charging through a change in the structural conformation of UBA1, not through direct interaction at the UBA1-Ub interface.
biochemical and crystallographic characterization of the two half-domains and the crystal structure of the larger, second catalytic cysteine half-domain of mouse ubiquitin-activating enzyme
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described.
ubiquitin-activating enzyme E1
, ubiquitin activating enzyme
, ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)
, ubiquitin-like modifier-activating enzyme 1
, Ubiquitin-conjugating enzyme E1
, A1S9T and BN75 temperature sensitivity complementing
, POC20 centriolar protein homolog
, UBA1, ubiquitin-activating enzyme E1 homolog A
, ubiquitin-activating enzyme E1, Chr X
, SUMO-activating enzyme subunit 2
, SUMO1 activating enzyme subunit 2
, Sumo-1 activating enzyme subunit 2
, anthracycline-associated resistance ARX
, ubiquitin-like 1 (sentrin) activating enzyme E1B
, ubiquitin-like 1 (sentrin) activating enzyme subunit 2
, ubiquitin-like 1-activating enzyme E1B