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anti-Unc-13 Homolog B (C. Elegans) (UNC13B) Antibodies

UNC13B is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UNC13B 10497 O14795
UNC13B 22249 Q9Z1N9
UNC13B 64830 Q62769
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Top anti-Unc-13 Homolog B (C. Elegans) Antibodies at antibodies-online.com

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of UNC13B Antibody (Center) (ABIN652852) in 293 cell line lysates (35 µg/lane). UNC13B (arrow) was detected using the purified polyclonal antibody. UNC13B Antibody (Center) (ABIN652852) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of panMunc13 on rat brain lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of panMunc13. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Mouse Rabbit Un-conjugated WB UNC13B Antibody (N-term) (ABIN657040) western blot analysis in mouse stomach tissue lysates (35 µg/lane). This demonstrates the UNC13B antibody detected the UNC13B protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Hela 5% SDS PAGE antibody diluted at 1:5000 IHC-P Image Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using UNC13B, antibody at 1:500 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using UNC13B, antibody at 1:500 dilution. WB Image Sample (30 ug of whole cell lysate) A: 293T 5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Rat Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Goat Un-conjugated ELISA   100 μg Log in to see 4 to 5 Days
$221.76
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Mouse Un-conjugated IHC, ELISA   100 μg Log in to see 8 to 10 Days
$793.83
Details

UNC13B Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Unc-13 Homolog B (C. Elegans) Antibodies

  1. Mouse (Murine) Monoclonal UNC13B Primary Antibody for IF, WB - ABIN968305 : Betz, Ashery, Rickmann, Augustin, Neher, Südhof, Rettig, Brose: Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. in Neuron 1998 (PubMed)
    Show all 5 references for ABIN968305

  2. Human Polyclonal UNC13B Primary Antibody for FACS, WB - ABIN652852 : Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: The consensus coding sequences of human breast and colorectal cancers. ... in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for ABIN652852

  3. Mouse (Murine) Polyclonal UNC13B Primary Antibody for WB - ABIN657040 : Trégouet, Groop, McGinn, Forsblom, Hadjadj, Marre, Parving, Tarnow, Telgmann, Godefroy, Nicaud, Rousseau, Parkkonen, Hoverfält, Gut, Heath, Matsuda, Cox, Kazeem, Farrall, Gauguier, Brand-Herrmann, Cambien, Lathrop, Vionnet,: G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes. in Diabetes 2008 (PubMed)

More Antibodies against Unc-13 Homolog B (C. Elegans) Interaction Partners

Human Unc-13 Homolog B (C. Elegans) (UNC13B) interaction partners

  1. The 1-5-8-26 CaM (show CALM1 Antibodies) binding motif discovered in Munc13-1 (show UNC13A Antibodies) cannot be induced in the classical CaM (show CALM1 Antibodies) target skMLCK (show MYLK2 Antibodies), indicating unique features of the Munc13 CaM (show CALM1 Antibodies) binding motif.

  2. Munc13-1 (show UNC13A Antibodies) regulates insulin (show INS Antibodies) exocytosis

  3. MUNC13-4 (show UNC13D Antibodies) mutations play a role in the development of familial haemophagocytic lymphohistiocytosis subtype 3 through a defective cytotoxic pathway

  4. Data suggest that diacylglycerol-activated hmunc13 serves as an effector of Rab34 (show RAB34 Antibodies), mediating lysosome-Golgi trafficking.

  5. Data identified a polymorphism in the UNC13B gene associated with nephropathy. UNC13B mediates apopotosis in glomerular cells in the presence of hyperglycemia, an event occurring early in the development of nephropathy.

  6. In the bound state, the hydrophobic anchor residue of the calmodulin (CaM (show CALM1 Antibodies))-binding motif in Munc13 contacts two distinct methionine residues in the carboxyl-terminal domain of CaM (show CALM1 Antibodies).

  7. mechanistic basis for high glucose-induced protein secretion is through interaction of munc13 and rab34 (show RAB34 Antibodies), indicating a potentially critical role for this newly described pathway in the pathogenesis of DN.

Mouse (Murine) Unc-13 Homolog B (C. Elegans) (UNC13B) interaction partners

  1. Data demonstrate that Munc13-1 (show UNC13A Antibodies) and DOC2B (show DOC2B Antibodies) have different effects on network activity and that by enhancing asynchronous release, DOC2B (show DOC2B Antibodies) exerts its properties to increase spiking activity and elevate synchronization between neurons within network bursts

  2. Munc13-1 (show UNC13A Antibodies) isoform is functionaly redundant in cytotoxic T lymphocytes.

  3. betaARs couple to a cAMP/Epac (show RAPGEF3 Antibodies)/PLC (show HSPG2 Antibodies)/Munc13-1 (show UNC13A Antibodies)/Rab3a (show RAB3A Antibodies)/RIM1a (show RIMS1 Antibodies)-dependent pathway to enhance glutamate (show GRIN1 Antibodies) release at cerebrocortical nerve terminals.

  4. Our data establish Munc13-1 (show UNC13A Antibodies) as a major presynaptic target of Ca(2 (show CA2 Antibodies)+)-Calmodulin (show Calm2 Antibodies) signaling and show that the Ca(2 (show CA2 Antibodies)+)-Calmodulin (show Calm2 Antibodies)-Munc13-1 (show UNC13A Antibodies) complex is a pivotal component of the molecular machinery that determines short-term synaptic plasticity characteristics.

  5. The Munc13 gene family encodes molecules located at the synaptic active zone that regulate the reliability of synapses to encode information over a wide range of frequencies in response to action potentials.

  6. This study demonistrated that Munc13 genotype regulates secretory amyloid precursor protein (show APP Antibodies) processing via postsynaptic glutamate (show GRIN1 Antibodies) receptors

  7. Mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1 (show UNC13A Antibodies)) plays a role in the recruitment of newcomer insulin (show INS Antibodies) granules in both first and second phases of glucose-stimulated insulin (show INS Antibodies) secretion in mouse islets.

  8. Munc13-1 (show UNC13A Antibodies)/2 were shown to facilitate dense-core vesicle fusion but, unlike for synaptic vesicles, were not essential for dense-core vesicle release.

  9. The composition of Munc13 isoforms in a neuron differentially controls its short-term synaptic plasticity characteristics.

  10. photoreceptor ribbon synapses and conventional synapses differ fundamentally with regard to their dependence on synaptic vesicles priming proteins of the Munc13 family

Cow (Bovine) Unc-13 Homolog B (C. Elegans) (UNC13B) interaction partners

  1. Chromaffin cell vesicle-priming by brain-specific (show CALY Antibodies) ubMunc13 isoform 2 is calcium ion (Ca2 (show CA2 Antibodies)+) dependent but independent of calmodulin (show KRIT1 Antibodies) binding to ubMunc13 isoform 2.

Unc-13 Homolog B (C. Elegans) (UNC13B) Antigen Profile

Protein Summary

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Gene names and symbols associated with UNC13B

  • unc-13 homolog B (C. elegans) (UNC13B) antibody
  • unc-13 homolog B (C. elegans) (Unc13b) antibody
  • MUNC13 antibody
  • Munc13-1 antibody
  • Munc13-2 antibody
  • UNC13 antibody
  • Unc13a antibody
  • UNC13B antibody
  • Unc13h1 antibody
  • Unc13h2 antibody

Protein level used designations for UNC13B

unc-13 homolog B (C. elegans) , protein unc-13 homolog B , protein unc-13 homolog B-like , homolog of rat Munc13 (diacylglycerol-binding) , munc13-2 , UNC-13 homolog 1 , munc13 , unc-13 homolog A , unc13 homolog 1 , unc-13 B-like protein

GENE ID SPECIES
464150 Pan troglodytes
697393 Macaca mulatta
738137 Pan troglodytes
100172629 Pongo abelii
100055666 Equus caballus
100405414 Callithrix jacchus
100472307 Ailuropoda melanoleuca
100593085 Nomascus leucogenys
10497 Homo sapiens
22249 Mus musculus
530692 Bos taurus
64830 Rattus norvegicus
Selected quality suppliers for anti-Unc-13 Homolog B (C. Elegans) (UNC13B) Antibodies
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