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The protein encoded by MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Additionally we are shipping V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Kits (22) and V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Proteins (8) and many more products for this protein.
Showing 10 out of 97 products:
Human Monoclonal MAF Primary Antibody for ELISA, WB - ABIN396683
Kim, Lee, Jung, Lee, Chung, Kim: Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. in Journal of human genetics 2010
Show all 5 references for ABIN396683
Human Monoclonal MAF Primary Antibody for WB - ABIN396687
Fontaine-Bisson, Renström, Rolandsson, , Payne, Hallmans, Barroso, Franks: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. in Diabetologia 2010
Show all 5 references for ABIN396687
Human Polyclonal MAF Primary Antibody for EMSA, EIA - ABIN1108101
Vial, Perez, Castellazzi: Transcriptional control of SPARC by v-Jun and other members of the AP1 family of transcription factors. in Oncogene 2000
Human Monoclonal MAF Primary Antibody for ELISA, WB - ABIN517678
Moreaux, Hose, Jourdan, Reme, Hundemer, Moos, Robert, Moine, De Vos, Goldschmidt, Klein: TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines. in Haematologica 2007
Human Polyclonal MAF Primary Antibody for ELISA, WB - ABIN1533536
Chesi, Bergsagel, Shonukan, Martelli, Brents, Chen, Schröck, Ried, Kuehl: Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma. in Blood 1998
Human Polyclonal MAF Primary Antibody for WB - ABIN391533
Li, Xiao, Wu, Qiu: Over-expression of c-maf by chondrocytes in osteoarthritis. in The Journal of international medical research 2009
Chicken Polyclonal MAF Primary Antibody for WB - ABIN2792536
Gosmain, Avril, Mamin, Philippe: Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. in The Journal of biological chemistry 2007
MafB (show MAFB Antibodies) and c-Maf have different expression patterns in macrophages, suggesting differences in function.
HERC4 (show HERC4 Antibodies) mediates c-Maf ubiquitination and delays growth of multiple myeloma.
Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin (show CRYAA Antibodies) both directly and indirectly via up-regulation of c-Maf.
Tec (show NR4A3 Antibodies) enhances c-Maf-dependent IL-4 (show IL4 Antibodies) promoter activity. This effect of Tec (show NR4A3 Antibodies) is counteracted by Ptpn22 (show PTPN22 Antibodies), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity.
endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA (show MAFA Antibodies) binding, and thus, the inhibition of small-Maf activity can improve beta-cell function
The melanoma microenvironment contributes to skewing of CD8 (show CD8A Antibodies) T cell differentiation programs, in part by TGFbeta (show TGFB1 Antibodies)/IL-6 (show IL6 Antibodies)-mediated induction of Maf.
Sox5 (show SOX5 Antibodies) physically associates with c-Maf via the HMG (show SSRP1 Antibodies) domain of Sox5 (show SOX5 Antibodies) and DNA-binding domain of c-Maf, and Sox5 (show SOX5 Antibodies) together with c-Maf directly activates the promoter of RORgammat in CD4 (show CD4 Antibodies)(+) T cells.
KLF13 (show KLF13 Antibodies) directly binds to IL-4 (show IL4 Antibodies) promoter regions and synergizes with c-Maf to positively regulate IL-4 (show IL4 Antibodies) expression.
The p53 (show TP53 Antibodies) transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf.
Translocations between IGH and MAF may arise only in the absence of close proximity to the more frequent partners in multiple myeloma.
Data suggest miR (show MLXIP Antibodies)-1290 as the new oncomiR involved in laryngeal squamous cell carcinoma pathogenesis probably through downregulation of its target genes MAF and ITPR2 (show ITPR2 Antibodies).
Results suggest that MAF is a mediator of breast cancer bone metastasis. 16q23 gain or MAF protein overexpression in tumors may help to select patients at risk of bone relapse.
Differential effect of cataract-associated mutations in MAF on transactivation of MAF target crystalline genes.
Study added a novel insight for c-MAF ubiquitination and degradation, suggesting that c-MAF stability is strictly regulated.
Disease-causing mutations were demonstrated to impair proper MAF phosphorylation, ubiquitination and proteasomal degradation, perturbed gene expression in primary skin fibroblasts, and induced neurodevelopmental defects in an in vivo model.
MAF has a role in mediating crosstalk between Ras-MAPK (show MAPK1 Antibodies) and mTOR (show FRAP1 Antibodies) signaling in NF1 (show NF1 Antibodies)
LPS (show IRF6 Antibodies) promotes PDCD4 (show PDCD4 Antibodies) degradation via a pathway involving PI3K (show PIK3CA Antibodies) and mTOR (show FRAP1 Antibodies), releasing Twist2 (show TWIST2 Antibodies), which induces IL-10 (show IL10 Antibodies) via c-Maf.
All four of the genes originally identified as showing genome-wide significance (IRF6 (show IRF6 Antibodies), ABCA4 (show ABCA4 Antibodies) and MAF, plus the 8q24 region) were confirmed in this independent sample of trios (who were primarily of European and Southeast Asian ancestry).
Results imply a regulatory role for TMEM18 (show TMM18 Antibodies), BDNF (show BDNF Antibodies), MTCH2 (show MTCH2 Antibodies) and NEGR1 (show NEGR1 Antibodies) in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1 (show NPC1 Antibodies), PTER (show PTER Antibodies) and SH2B1 (show SH2B1 Antibodies) were not regulated.
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog
, c-Maf long form
, proto-oncogene c-maf
, transcription factor Maf
, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene
, T lymphocyte c-maf long form
, c-maf proto-oncogene
, proto-oncogene c-Maf
, transcription factor Maf-2
, Proto-oncogene c-maf