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anti-VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) Antibodies

The protein encoded by VAPB is a type IV membrane protein found in plasma and intracellular vesicle membranes. Additionally we are shipping VAPB Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VAPB 9217 O95292
VAPB 60431 Q9Z269
VAPB 56491  
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Top anti-VAPB Antibodies at antibodies-online.com

Showing 10 out of 67 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB VAPB Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the VAPB antibody detected the VAPB protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, IHC (p), ELISA, WB Immunochemical staining of human VAPB in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human VAPB in human liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Mouse Un-conjugated IHC   100 μg Log in to see 8 to 10 Days
$793.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 16 Days
$273.90
Details
Human Rabbit Un-conjugated IP, WB VAPB MaxPab rabbit polyclonal antibody. Western Blot analysis of VAPB expression in HepG2. VAPB MaxPab rabbit polyclonal antibody. Western Blot analysis of VAPB expression in mouse lung. 100 μL Log in to see 9 Days
$418.57
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged VAPB is approximately 3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB   500 μg Log in to see 8 to 10 Days
$493.17
Details
Human Sheep Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$969.83
Details

VAPB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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More Antibodies against VAPB Interaction Partners

Human VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. Our work revealed that VAP-A/B knockdown impaired the processing and secretion of PAUF, which is one of the cargo proteins of carriers of the trans-Golgi network to the cell surface.

  2. Heterozygous P56S Vapb knock-in mice show mild age-dependent defects in motor behaviors as characteristic features of the disease. The homozygous P56S Vapb knock-in mice show more severe defects compared with heterozygous mice reflecting the dominant and dose-dependent effects of P56S mutation.

  3. VAPB inhibited the degradation of DeltaF508-CFTR in the ER through interactions with the RMA1-Derlin-BAP31-VCP pathway.

  4. Study characterizes the human VAPB-HCV NS5B interaction and reveals that NS5B C-linker is intrinsically disordered in solution but capable of binding the human VAPB-MSP (show MSMB Antibodies) domain which overlaps with those for binding HCV NS5A and human Eph (show EPHA1 Antibodies) receptors.

  5. The VAPB and its interacting partners cooperatively regulate protein trafficking through the ERGIC by modulating PtdIns4P levels.

  6. results suggest that the binding of vesicle-associated membrane protein-associated protein B(VAP-B) to Rab3 GTPase activating protein 1(RAB3GAP1 (show RAB3GAP1 Antibodies)) is implicated in the regulation of nuclear envelope formation through ER-Golgi intermediate compartment

  7. P56S-VAPB was found to suppress adipocyte differentiation by promoting the activation of the ATF4 (show ATF4 Antibodies)-CHOP (show DDIT3 Antibodies) pathway

  8. The repertoire of VAPB interactors is more diverse than previously anticipated and link VAPB to the function of ATPase (show DNAH8 Antibodies) complexes such as p97 (show EIF4G2 Antibodies)/FAF1 (show FAF1 Antibodies) and ASNA1 (show ASNA1 Antibodies)/transmembrane-domain recognition complex.

  9. In patients with familial or sporadic amyotrophic lateral sclerosis (ALS (show IGFALS Antibodies)) from Portugal, Iceland and Sweden no association is found with disease and VAMP (show VAMP Antibodies)-associated protein type B (VAPB) mutations.

  10. Findings provide new pathophysiological mechanisms of P56S VAPB that differentially affect the function and survival of corticospinal and spinal motor neurons in familial amyotrophic lateral sclerosis 8.

Mouse (Murine) VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB) interaction partners

  1. To identify pathological defects in animals expressing the P56S mutant VAPB protein at physiological levels in the appropriate tissues, we have generated Vapb knock-in mice

  2. The disruption of the IRE1 (show ERN1 Antibodies)-XBP1 (show XBP1 Antibodies) pathway is a cause for the reduced myotube formation in P56S-VAPB-mutation expressing cells.

  3. Vapb knock-out mice exhibit abnormal muscular triacylglycerol levels and FoxO (show FOXO3 Antibodies) target gene transcriptional responses to fasting and refeeding

  4. Mice knocked-out for Vapb showed mild motor deficits after 18 months of age.

  5. VapB positively regulates RANKL (show TNFSF11 Antibodies)-mediated osteoclastogenesis via PLCgamma2 (show PLCG2 Antibodies)-Ca(2 (show CA2 Antibodies)+)-NFAT (show NFATC1 Antibodies) signaling

  6. Co-expression of mutant protein-associated protein B (show LEPREL2 Antibodies) (VAPB) enhances the transactive response DNA-binding protein (show HSF4 Antibodies)-43 (TDP-43 (show TARDBP Antibodies))-induced motor neuronal cell death while that of wild type-VAPB attenuates it.

  7. Adeno (show ADORA2A Antibodies)-associated viral-mediated over-expression of both wild-type and mutated form of human VAPB selectively induces death of primary motor neurons, albeit with different kinetics.

  8. However, VAPBP56S but not VAPBwt transgenic mice develop cytoplasmic TDP-43 (show TARDBP Antibodies) accumulations within spinal cord motor neurons that were first detected at 18 months of age.

  9. The total loss of VAPB function in unfolded protein response, induced by one P56S mutant allele, may contribute to the development of P56SVAPB- induced amyotrophic lateral sclerosis.

VAPB Antigen Profile

Protein Summary

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.

Gene names and symbols associated with VAPB

  • vesicle-associated membrane protein-associated protein B/C (Tsp_07972) antibody
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (VAPB) antibody
  • VAMP-associated protein B/C (LOC788595) antibody
  • VAMP-associated protein B/C (LOC100350714) antibody
  • VAMP (vesicle-associated membrane protein)-associated protein B and C (Vapb) antibody
  • vesicle-associated membrane protein, associated protein B and C (Vapb) antibody
  • AI225786 antibody
  • AI840687 antibody
  • AI848259 antibody
  • ALS8 antibody
  • D2Abb2e antibody
  • R75548 antibody
  • VAMP-B antibody
  • Vamp33b antibody
  • VAP-B antibody
  • VAP33b antibody

Protein level used designations for VAPB

vesicle-associated membrane protein-associated protein B/C , VAMP (vesicle-associated membrane protein)-associated protein B and C , VAMP-associated protein B/C , VAMP-associated 33 kDa protein , VAMP-B , VAMP-associated protein B , VAP-B , vesicle-associated membrane protein-associated protein B , vesicle-associated membrane protein, associated protein B and C , VAMP-associated protein 33b

GENE ID SPECIES
10906529 Trichinella spiralis
469984 Pan troglodytes
788595 Bos taurus
100350714 Oryctolagus cuniculus
9217 Homo sapiens
419317 Gallus gallus
100144536 Sus scrofa
326580 Bos taurus
60431 Rattus norvegicus
56491 Mus musculus
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