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May act as a specific coactivator for the mammalian TEFs (By similarity).. Additionally we are shipping VGLL3 Proteins (7) and many more products for this protein.
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Human Polyclonal VGLL3 Primary Antibody for WB - ABIN2786158
Maeda, Chapman, Stewart: Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. in The Journal of biological chemistry 2002
VGLL3 is involved in tumor suppressor pathways, a feature that is characterized by the absence of VGLL3 expression in high-grade serous ovarian carcinomas samples.
vestigial-like 3 (Vgll3) is an inhibitor of adipogenesis
data suggest that the amplification and overexpression of YAP1 (show YAP1 Antibodies) and VGLL3 could be involved in oncogenesis and progression of soft tissue sarcomas
This protein was named Vestigial-like 3, because it is related to the Drosophila protein Vestigial. Like other members of this family, it contains a consensus TEF-1 (show TEAD1 Antibodies) and MEF2 (show MEF2A Antibodies)(TDU (show VGLL1 Antibodies))interaction domain.
Loss of VGLL3 expression was observed in tumors derived from mouse xenograft models.
In embryonic and fetal development VITO-2 is mainly expressed in the myogenic lineage.Later developmental stages it is found in the nervous system.In adult mice it was detected in skeletal muscle, heart, kidney, liver, brain.
May act as a specific coactivator for the mammalian TEFs (By similarity).
transcription cofactor vestigial-like protein 3
, vestigial like 3 (Drosophila)
, colon carcinoma related protein
, vestigial-like 3