anti-Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) Antibodies

Vitamin K is essential for blood clotting but must be enzymatically activated. Additionally we are shipping VKORC1 Kits (13) and VKORC1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VKORC1 79001 Q9BQB6
VKORC1 27973 Q9CRC0
VKORC1 309004 Q6TEK4
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Top anti-VKORC1 Antibodies at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Rabbit Anti-VKORC1 Antibody Catalog Number: ARP63330_P050 Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec WB Suggested Anti-VKORC1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated IHC (p), WB VKORC1 Antibody (N-term) (ABIN652040) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the VKORC1 antibody detected the VKORC1 protein (arrow). VKORC1 Antibody (N-term) (ABIN652040) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IHC, WB   100 μg Log in to see 7 to 9 Days
$537.17
Details
Human Rabbit Un-conjugated ELISA, IHC, WB   200 μL Log in to see 7 to 9 Days
$793.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL Log in to see 7 to 9 Days
$1,013.83
Details

VKORC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,


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Mouse (Murine)


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Rat (Rattus)


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Top referenced anti-VKORC1 Antibodies

  1. Human Polyclonal VKORC1 Primary Antibody for EIA, IHC (fro) - ABIN493558 : Li, Chang, Jin, Lin, Khvorova, Stafford: Identification of the gene for vitamin K epoxide reductase. in Nature 2004 (PubMed)
    Show all 3 references for 493558

More Antibodies against VKORC1 Interaction Partners

Human Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. Patients with non-variceal upper gastrointestinal bleeding caused by the use of NSAID or low dose aspirin are more frequent carriers of the VKORC1-1639 G>A polymorphism.

  2. Our results supported an enzyme activating role for rs56314408C of VKORC1 while rs9923231G>A had no evidence of being functional

  3. Polymorphisms in VKORC1 partially affected daily warfarin dosage requirements. VKORC1 genotype and height are the primary determinants influencing warfarin dosage in Japanese pediatric patients.

  4. VKORC polymorphism affects PC dosage in the initiation as well as the maintenance phase. High rates of bleeding complications and thromboembolic events were found at the beginning of PC therapy in VAD (show KCTD1 Antibodies) patients.

  5. Genetic variants of CYP2C9 (show CYP2C9 Antibodies)/VKORC1 and age are significant determinants of the maintenance dose of warfarin in patients with atrial fibrillation/valve replacement.

  6. The Arg98Trp mutation disrupts an ER retention motif of VKORC1 leading to mislocalisation of the protein to outside the endoplasmatic reticulum. In this review, we summarize the clinical data, diagnosis, therapy and molecular pathomechanism of VKCFD2.

  7. Possession of CYP2C9 (show CYP2C9 Antibodies)*2 and/or CYP2C9 (show CYP2C9 Antibodies)*3 allele variants is associated with lower time of international normalized ratio (INR (show INSR Antibodies)) in the therapeutic range (TTR (show TTR Antibodies)) values and warfarin dose variations in aortic valve replacement patients, the latter affected also by VKORC1 c.-1693G>A polymorphism

  8. Three SNPs (CYP2C9 (show CYP2C9 Antibodies) *2, *3 and VKORC1 c.-1639G > A) were genotyped by electrochemical detection using a sandwich-type format that included a 3' short thiol capture probe and a 5' ferrocene-labeled signal probe.

  9. Our results show that anticoagulated patients have a high risk of adverse events if they are carriers of 1 or more genetic polymorphisms in the VKORC1 (rs9923231) and CYP2C9 (show CYP2C9 Antibodies) (rs1799853 and rs1057910) genes.

  10. The VKORC1 (-1693 G>A) AA genotype was associated with fewer cases of DVT (odds ratio = 0.435; 95% confidence interval 0.205-0.991; P = .031).

Mouse (Murine) Vitamin K Epoxide Reductase Complex, Subunit 1 (VKORC1) interaction partners

  1. quantified mRNA levels for VKORC1, VKORC1L1, GGCX (show GGCX Antibodies), and NQO1 (show NQO1 Antibodies) and measured VKOR enzymatic activities in 29 different tissues

  2. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX (show GGCX Antibodies)) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1.

  3. The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.

  4. molecular cloning [VKORC1]

  5. The genetic basis for resistance to anticoagulants lies in mutations in Vkorc1.

  6. An analysis of novel mutations show that the VKORC1 gene is the main target for spontaneous mutations conferring warfarin resistance.

  7. Each VKORC1 T-allele present in patients from the Rotterdam anticoagulation therapy study is shown to decrease the required acenocoumarol dosage by 5.1 mg/week.

VKORC1 Antigen Profile

Protein Summary

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

Gene names and symbols associated with VKORC1

  • vitamin K epoxide reductase complex, subunit 1 (VKORC1) antibody
  • vitamin K epoxide reductase complex subunit 1 (vkorc1) antibody
  • vitamin K epoxide reductase complex, subunit 1 (vkorc1) antibody
  • Vitamin-K epoxide reductase (Vkor) antibody
  • vitamin K epoxide reductase complex, subunit 1 (Vkorc1) antibody
  • BP1071 antibody
  • CG33544 antibody
  • D7Wsu86e antibody
  • Dmel\\CG33544 antibody
  • EDTP308 antibody
  • HDC06808 antibody
  • IMAGE3455200 antibody
  • MGC89620 antibody
  • MST134 antibody
  • MST576 antibody
  • VKCFD2 antibody
  • VKOR antibody
  • VKORC1 antibody

Protein level used designations for VKORC1

phylloquinone epoxide reductase , vitamin K1 epoxide reductase (warfarin-sensitive) , vitamin K epoxide reductase complex, subunit 1 , CG33544-PA , Vkor-PA , vitamin K dependent clotting factors deficiency 2 , vitamin K epoxide reductase complex subunit 1 , vitamin K1 2,3-epoxide reductase subunit 1 , Warfarin resistance

GENE ID SPECIES
404205 Gallus gallus
446034 Takifugu rubripes
448775 Xenopus (Silurana) tropicalis
479775 Canis lupus familiaris
3346188 Drosophila melanogaster
79001 Homo sapiens
27973 Mus musculus
309004 Rattus norvegicus
445422 Bos taurus
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