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WFDC2 encodes a protein that is a member of the WFDC domain family. Additionally we are shipping WFDC2 Proteins (29) and WFDC2 Kits (20) and many more products for this protein.
Showing 10 out of 152 products:
Human Monoclonal WFDC2 Primary Antibody for ELISA, WB - ABIN396057
Hellstrom, Heagerty, Swisher, Liu, Jaffar, Agnew, Hellstrom: Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms. in Cancer letters 2010
Show all 5 references for ABIN396057
Human Polyclonal WFDC2 Primary Antibody for DB, EIA - ABIN492984
Galgano, Hampton, Frierson: Comprehensive analysis of HE4 expression in normal and malignant human tissues. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006
Show all 4 references for ABIN492984
Human Polyclonal WFDC2 Primary Antibody for DB, EIA - ABIN2712091
Alberti, Bachelot, Duc, Biota, Blay: A spliced isoform of interleukin 6 mRNA produced by renal cell carcinoma encodes for an interleukin 6 inhibitor. in Cancer research 2005
Show all 4 references for ABIN2712091
Human Monoclonal WFDC2 Primary Antibody for ELISA, WB - ABIN564522
Yuan, Duan, Yang, Luo, Xi: Detection of serum human epididymis secretory protein 4 in patients with ovarian cancer using a label-free biosensor based on localized surface plasmon resonance. in International journal of nanomedicine 2012
Human Polyclonal WFDC2 Primary Antibody for ELISA, WB - ABIN4276002
Huhtinen, Suvitie, Hiissa, Junnila, Huvila, Kujari, Setälä, Härkki, Jalkanen, Fraser, Mäkinen, Auranen, Poutanen, Perheentupa: Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts. in British journal of cancer 2009
HE4 is elevated less frequently than CA125 (show MUC16 Antibodies) in benign adnexal tumors, regardless of age or menopausal status
HE4 expression in biopsy material from endometrial hyperplasia can be monitored and regulated by progestin. Changes in the expression of HE4 during progestin therapy regimens can predict therapy response or indicate progestin resistance for medium- and low-risk endometrial hyperplasia.
Serum HE4 levels were significantly elevated in children and adults with cystic fibrosis (show S100A8 Antibodies) (CF) compared to controls. Abnormal but lower HE4 concentrations were found in cases of severe bronchitis, asthma, pneumonia, and bronchiectasis. HE4 mRNA levels were significantly upregulated in CF vs. non-CF airway biopsy specimens.
Human epididymis protein 4 induces chemoresistance against anti-cancer drugs and activates the AKT (show AKT1 Antibodies) and Erk (show EPHB2 Antibodies) pathways to enhance tumor survival. Human epididymis protein 4 expression in ovarian cancer tissue is associated with a worse prognosis for epithelial ovarian cancer patients.
This study found that increased serum HE4 is independently associated with the development of Lupus Nephritis and Chronic Kidney Disease in Systemic Lupus Erythematosus patients.
The present study displayed the most fundamental and full-scale data to show differentially expressed genes in response to HE4
We found the high specificity of HE4 and CA125 (show MUC16 Antibodies) while differentiating ovarian benign diseases from epithelial ovarian cancer in postmenopausal women and the high sensitivity of CA125 (show MUC16 Antibodies) in detecting epithelial ovarian cancer in premenopausal patients
HE4 levels at primary diagnosis correlate with an increased risk of endometrial cancer recurrence, particularly in cases of endometrioid histotype, and they may help to recognize patients who may need a more intensive follow-up
Overexpression of HE4 promotes collateral resistance to cisplatin and paclitaxel, and downregulation of HE4 partially reverses this chemoresistance.
High Serum HE4 level is associated with epithelial ovarian cancer.
Causal testing implicates Wfdc2 and Hdac3 (show HDAC3 Antibodies) as novel genes affecting high density lipoprotein levels
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
WAP four-disulfide core domain 2
, WAP four-disulfide core domain 3
, WAP four-disulfide core domain protein 2
, WAP domain containing protein HE4-V4
, epididymal protein 4
, epididymal secretory protein E4
, epididymis-specific, whey-acidic protein type, four-disulfide core
, major epididymis-specific protein E4
, putative protease inhibitor WAP5
, WAP domain-containing protein HE4
, epididymal secretory protein 4
, epididymal protein BE-20