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WW Domain Containing Transcription Regulator 1 Proteins (WWTR1)

WWTR1 encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. Additionally we are shipping WWTR1 Antibodies (51) and WWTR1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWTR1 25937 Q9GZV5
Mouse WWTR1 WWTR1 97064 Q9EPK5
Rat WWTR1 WWTR1 295062  
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Top WWTR1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

WWTR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for WW Domain Containing Transcription Regulator 1 (WWTR1) Interaction Partners

Zebrafish WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Yap (show YAP1 Proteins)/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.

  2. Taz (show TAZ Proteins) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.

  3. Taz (show TAZ Proteins)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles

  4. When transcriptional coactivators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.

  5. TAZ (show TAZ Proteins) has a critical role in osteoblast differentiation in vivo

Human WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. SCLC cell lines of the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) subgroup had higher sensitivity to the widely used anticancer agent for SCLC, topotecan.

  2. The activity of the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) transcriptional coactivators, was found to be regulated by metabolic pathways, such as aerobic glycolysis and mevalonate synthesis, and by the nutrient-sensing LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) and TSC (show SLC12A3 Proteins)-mTOR (show FRAP1 Proteins) pathways. (Review)

  3. Over expression of TAZ (show TAZ Proteins) was associated with abnormal expression of beta-catenin (show CTNNB1 Proteins), which is correlated with poor prognosis of patients with adenocarcinoma of the esophagogastric junction

  4. Our findings emphasize the tumorigenic role of TAZ (show TAZ Proteins) and may serve as the basis for new treatment strategies.

  5. Immortalized fibroblasts conditionally expressing active YAP (show YAP1 Proteins) or TAZ (show TAZ Proteins) mutant proteins overcome soft matrix limitations on growth and promote fibrosis

  6. Results revealed that TAZ (show TAZ Proteins) is a differentially expressed molecule in human hepatocellular carcinoma (HCC (show FAM126A Proteins)) suggesting it as an important regulator, TAZ (show TAZ Proteins) might be as a new diagnostic biomarker in HCC (show FAM126A Proteins).

  7. Results show TAZ (show TAZ Proteins) functioned as an oncogene (show RAB1A Proteins) and promoted pancreatic cancer epithelial-mesenchymal transition and progression.

  8. this article summarizes the current understanding of the biological functions of YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins), and how the regulation of these two proteins can be disrupted in cancer.[Review][

  9. TAZ (show TAZ Proteins) inhibits temozolomide induced apoptosis via upregulation of MCL-1 (show MCL1 Proteins) (myeloid cell leukemia 1) and high expression of TAZ (show TAZ Proteins) predicts a poor prognosis for GBM patients

  10. TAZ (show TAZ Proteins) and YAP (show YAP1 Proteins) are differentially regulated by hypoxia in cancer cells

Mouse (Murine) WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Results found that sclerostin (show SOST Proteins) enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (show TAZ Proteins)-responsive transcriptional activity and TAZ (show TAZ Proteins)-responsive gene expression, indicating a role for TAZ (show TAZ Proteins) as a regulator of adipogenesis by sclerostin (show SOST Proteins).

  2. Expression of TAZ (show TAZ Proteins) promotes embryonic neural stem cell maintenance by enhancing stemness of neural stem cells during mammalian brain development.

  3. Tead2 (show TEAD2 Proteins) transcription factors are crucial regulators of the cellular distribution of Yap (show YAP1 Proteins) and Taz (show TAZ Proteins), and together they control the expression of genes critical for EMT (show ITK Proteins) and metastasis.

  4. findings uncover important roles for Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) in cranial neural crest diversification and development

  5. Study discovered that YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) are bona fide downstream effectors of the alternative Wnt (show WNT2 Proteins) signaling pathway.

  6. Hippo signalling effectors, YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins), promote both the proliferation of intestinal stem/progenitor cells and their differentiation into goblet cells.

  7. This study identifies a novel mechanism of TAZ (show TAZ Proteins) regulation by YAP (show YAP1 Proteins), which has significant implications for our understanding of Hippo pathway regulation, YAP (show YAP1 Proteins)-isoform specific signaling, and the role of these proteins in cell proliferation, apoptosis, and tumorigenesis

  8. Disrupting Yap (show YAP1 Proteins)/Taz (show TAZ Proteins) activities enhances Ret (show RET Proteins) pathway activity and contributes to pathogenesis of lower urinary tract defects

  9. Immortalized fibroblasts conditionally expressing active YAP (show YAP1 Proteins) or TAZ (show TAZ Proteins) mutant proteins overcome soft matrix limitations on growth and promote fibrosis

  10. YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) regulate transcriptional elongation from the enhancer elements by recruiting the Mediator complex and promoting phenotypes of overgrowth and tumorigenesis

WWTR1 Protein Profile

Protein Summary

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.

Gene names and symbols associated with WWTR1

  • WW domain containing transcription regulator 1 (wwtr1)
  • WW domain containing transcription regulator 1 (WWTR1)
  • WW domain containing transcription regulator 1 (Wwtr1)
  • 2310058J06Rik protein
  • 2610021I22Rik protein
  • C78399 protein
  • Taz protein
  • WWTR1 protein

Protein level used designations for WWTR1

WW domain containing transcription regulator 1 , WW domain-containing transcription regulator protein 1 , taz , WW domain-containing transcription regulator protein 1-like , transcriptional co-activator with PDZ-binding motif , transcriptional coactivator with PDZ-binding motif , transcriptional coactivator with PDZ binding motif , transcriptional co-activator with PDZ-binding motif (TA)Z , transcriptional co-activator with PDZ-binding motif (TAZ)

GENE ID SPECIES
496155 Xenopus laevis
568008 Danio rerio
100050661 Equus caballus
100401831 Callithrix jacchus
100437619 Pongo abelii
100493170 Xenopus (Silurana) tropicalis
100522573 Sus scrofa
100592028 Nomascus leucogenys
25937 Homo sapiens
609743 Canis lupus familiaris
614786 Bos taurus
97064 Mus musculus
295062 Rattus norvegicus
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