WW and C2 Domain Containing 1 Proteins (WWC1)

The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Additionally we are shipping WW and C2 Domain Containing 1 Antibodies (49) and WW and C2 Domain Containing 1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
WWC1 23286 Q8IX03
WWC1 211652 Q5SXA9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top WW and C2 Domain Containing 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$510.36
Details
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$682.00
Details

WWC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for WW and C2 Domain Containing 1 (WWC1) Interaction Partners

Fruit Fly (Drosophila melanogaster) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. Merlin (show NF2 Proteins) and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.

  2. Kibra, a binding partner of Pez (show PTPN14 Proteins), stabilizes Pez (show PTPN14 Proteins) via WW-PY/PPxY interaction.

  3. Kibra regulates starvation-induced autophagy downstream of aPKC.

  4. In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.

  5. The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.

  6. Kibra functions as a tumor suppressor protein (show TP53 Proteins) that regulates Hippo signaling in conjunction with Merlin (show NF2 Proteins) and Expanded.

  7. Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

  8. Kibra predominantly acts in the Merlin (show NF2 Proteins) branch upstream of the core kinase cascade to regulate Hippo signaling.

Human WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. Ability to navigate in the wilderness benefits from episodic memory (KIBRA).

  2. Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3 (show CELSR3 Proteins)), NIPBL (show NIPBL Proteins) (Nipped (show RPL38 Proteins)-B-like), and FN1 (fibronectin 1 (show FN1 Proteins)).

  3. study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease

  4. show that KIBRA is overexpressed in human prostate tumors. Our studies uncover unexpected results and identify KIBRA as a tumor promoter in prostate cancer

  5. No significant differences in allelic or gene frequency distribution of KIBRA SNP rs17070145 were observed between schizophrenic and healthy control groups.

  6. WWC1 variants are involved in AMPA (show GRIA3 Proteins) receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.

  7. Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2 (show CA2 Proteins)/3 and CA4 (show CA4 Proteins)/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers

  8. decreased expression of the KIBRA gene on both mRNA and protein levels in depression, is reported.

  9. Phosphorylation-dependent regulation of the DNA damage response of Kibra protein in cancer cells

  10. Study did not find support for an association of KIBRA either alone or in combination with CLSTN2 with memory performance or hippocampal volume, nor did variation in these genes influence longitudinal memory decline or hippocampal atrophy in older adults

Mouse (Murine) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease

  2. KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta

  3. These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.

  4. KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  5. KIBRA functions in memory performance via interaction with PKMzeta.

WW and C2 Domain Containing 1 (WWC1) Protein Profile

Protein Summary

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with WWC1

  • kibra ortholog (kibra)
  • WW and C2 domain containing 1 (WWC1)
  • WW, C2 and coiled-coil domain containing 1 (Wwc1)
  • AA408228 protein
  • AU017197 protein
  • BC037006 protein
  • CG7552 protein
  • CG12600 protein
  • CG33967 protein
  • Dmel\\CG33967 protein
  • HBEBP3 protein
  • HBEBP36 protein
  • kib protein
  • KIBRA protein
  • l(3)02404 protein
  • l(3)j5C3 protein
  • l(3)neo42 protein
  • mKIAA0869 protein
  • ORE-2 protein
  • RE26350 protein

Protein level used designations for WWC1

CG33967-PA , kibra-PA , lethal (3) neo42 , HBeAg-binding protein 3 , WW, C2 and coiled-coil domain containing 1 , kidney and brain protein , protein KIBRA , protein WWC1 , WW domain-containing protein 1

GENE ID SPECIES
41783 Drosophila melanogaster
23286 Homo sapiens
211652 Mus musculus
Selected quality suppliers for WW and C2 Domain Containing 1 Proteins (WWC1)
Did you look for something else?