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Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). Additionally we are shipping WRNIP1 Kits (3) and WRNIP1 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal WRNIP1 Primary Antibody for WB - ABIN2775244
Tsurimoto, Shinozaki, Yano, Seki, Enomoto: Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. in Genes to cells : devoted to molecular & cellular mechanisms 2005
findings define the WHIP-TRIM14 (show TRIM14 Antibodies)-PPP6C (show PPP6C Antibodies) mitochondrial signalosome required for RIG-I (show DDX58 Antibodies)-mediated innate antiviral immunity.
WRNIP1 connects PCNA (show PCNA Antibodies) monoubiquitination with ATMIN (show ATMIN Antibodies)/ATM (show ATM Antibodies) to activate ATM (show ATM Antibodies) signalling in response to replication stress and contribute to the maintenance of genomic stability.
The authors show that WRNIP1 is directly involved in preventing uncontrolled MRE11 (show MRE11A Antibodies)-mediated degradation of stalled replication forks by promoting RAD51 (show RAD51 Antibodies) stabilization on ssDNA.
We propose that UBZ domains can be divided into at least two different types in terms of the ubiquitin-binding surfaces: the pol type and the WRNIP1 type
results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation
Mutated WRNIP1 with a deleted ATPase (show DNAH8 Antibodies) domain or with mutations in lysine residues accumulated in laser light irradiated sites, suggesting that the ATPase (show DNAH8 Antibodies) domain of WRNIP1 and ubiquitination of WRNIP1 are dispensable for the accumulation.
WHIP was identified as a partner/component of the nuclear envelope/nuclear pore complex (NPC (show NPC1 Antibodies)) and set forth to investigate a role for the protein positioned at the NPC (show NPC1 Antibodies).
These results indicate that WRNIP1 functions as a modulator for initiation or restart events during pol delta (show POLD1 Antibodies)-mediated DNA synthesis and that its ATPase (show DNAH8 Antibodies) activity is utilized to sense DNA ends and to regulate the extent of stimulation.
Werner helicase-interacting protein 1 binds polyubiquitin (show UBB Antibodies) via its zinc finger domain
analysis of the composite and regulated topography of Wrnip1 in the human nucleus highlights its potential role in replication and other nuclear transactions
Mutations in the Walker A motifs of the two proteins revealed that WRNIP1, but not WRN, must bind ATP before an efficient interaction can occur.
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
, Werner helicase interacting protein 1
, Werner helicase-interacting protein 1
, putative helicase RUVBL
, Werner helicasae interacting protein 1
, Werner syndrome homolog interacting protein
, werner helicase-interacting protein 1