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WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Additionally we are shipping WHSC1 Antibodies (40) and many more products for this protein.
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These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.
Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.
In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.
results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.
NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation
Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (show WHSC1L1 Proteins) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
It was observed that RE-IIBP induces MEIS1 (show MEIS1 Proteins)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20 (show RNF20 Proteins).
Results show that WHSC1 is overexpressed in Squamous cell carcinoma of the head and neck (SCCHN) and that it promotes cell-cycle progression through activation of NEK7 (show NEK7 Proteins), indicating its potential role as an oncogenic force in SCCHN.
The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.
The role of the shorter isoform (REIIBP) in myeloma cells was characterized and identified a clear and novel interaction of REIIBP with members of the SMN (show STMN1 Proteins) complex.
Haploinsufficiency of WHSC1 and/or LETM1 (show LETM1 Proteins) contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype.
WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies
Histone H3 (show HIST3H3 Proteins) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (show RUNX2 Proteins) and p300 (show NOTCH1 Proteins) in the activation of bone-related genes
all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 (show SETD8 Proteins) were not affected by ubH2A.
WHSC1 links transcription elongation to HIRA (show HIRA Proteins)-mediated histone H3.3 (show H3F3A Proteins) deposition.
H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Wolf-Hirschhorn syndrome candidate 1 protein
, Wolf-Hirschhorn syndrome candidate 1
, probable histone-lysine N-methyltransferase NSD2
, IL5 promoter REII region-binding protein
, histone-lysine N-methyltransferase NSD2
, multiple myeloma SET domain containing protein type III
, nuclear SET domain-containing protein 2
, trithorax/ash1-related protein 5
, multiple myeloma SET domain-containing protein
, wolf-Hirschhorn syndrome candidate 1 protein homolog