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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. Additionally we are shipping YY1 Transcription Factor Antibodies (147) and YY1 Transcription Factor Kits (6) and many more products for this protein.
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YY1 is essential for Xenopus development in neural ectoderm differentiation, neural crest specification and directing neural crest mesenchyme formation by blocking slug (show SNAI2 Proteins)
Yin Yang 1 transcription factor assembly into messenger ribonucleoprotein particles requires direct RNA binding activity
Results show that the YY1-RNA interaction is highly stable, and that YY1 possesses the ability to interact with structurally divergent RNA substrates.
results suggest that YY1a regulates PS receptor expression that linked to function of PSR (show JMJD6 Proteins)-phagocyte mediated apoptotic cell engulfment during development
YY1 promotes zebrafish liver steatosis and lipotoxicity by inhibiting CHOP-10 (show DDIT3 Proteins) expression.
Study demonstrated that beta-arrestin1 (show ARRB1 Proteins) is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 (show ARRB1 Proteins) binds to and sequesters the PcG recruiter YY1, thus relieving PcG-mediated repression of cdx4-hox (show MSH2 Proteins) pathway.
PRE-PIK3C2B (show PIK3C2B Proteins) interacts directly with YY1 in vitro and recruits PRC2 complex in vivo. The localization of PcG proteins including YY1 to PRE-PIK3C2B (show PIK3C2B Proteins) in HEK (show EPHA3 Proteins) cells is decreased on knock-down of either YY1 or SUZ12 (show SUZ12 Proteins).
YY1 promotes mTORC2 (show CRTC2 Proteins)-mediated AKT (show AKT1 Proteins) activation
Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS (show SARS Proteins)) to form a SerRS (show SARS Proteins)/YY1 complex which functions as a negative effector to regulate vegfa (show VEGFA Proteins) transcription through binding a distal segment of the vegfa (show VEGFA Proteins) promoter, while NFKB1 (show NFKB1 Proteins) serves as a positive effector through outcompeting SerRS (show SARS Proteins)/YY1 for binding at the same distal segment.
these results define a clinical syndrome caused by haploinsufficiency of YY1 through dysregulation of key transcriptional regulators.
Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described.
ZFs of YY1 are able to interact with multiple RNA sequences, and that their specificity is not limited to putative endogenous RNA target Xist. The mode of interaction appears to be distinct from both the DNA binding of YY1 and the RNA binding of other classical ZF proteins.
the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP (show BCCIP Proteins) promoter region. Our findings strongly indicate that BCCIP (show BCCIP Proteins) is a potential target gene of the INO80/YY1 complex.
miR (show MLXIP Proteins)-215 is downregulated in colon cancer and it suppresses colon cancer cell proliferation, migration and invasion by directly targeting YY1
High YY1 expression is Associated with Endometrial Cancer.
Our results suggested that YY1 depletion repressed prostate cancer cell viability and proliferation and induced apoptosis at least in a miR (show MLXIP Proteins)-146a-assisted manner.
DNA binding domain of YY1 is necessary for X-chromosome inactivation in activated B cells, as ex-vivo YY1 deletion results in loss of inactive X (Xi) chromosome heterochromatin marks and up-regulation of X-linked genes.
Transcriptome analysis revealed that YY1 is required for mitochondrial gene expression, and ultrastructural analysis confirmed compromised mitochondrial integrity in the mutant intestine.
regulates broad general processes throughout all stages of B-cell differentiation: normally activates genes involved in mitochondrial bioenergetics; normally down-regulates genes involved in transcription, mRNA splicing, NF-kappaB (show NFKB1 Proteins) signaling pathways, the AP-1 (show JUN Proteins) transcription factor network, chromatin remodeling, cytokine signaling pathways, cell adhesion, and cell proliferation
Results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in germinal center (GCs (show UGCG Proteins)) and between survival and death of GC B (show NPR2 Proteins) cells.
YY1 is required for germinal center B cell development.
Dp71 (show DMD Proteins) expression in hepatic cells is carried out, in part, by YY1-, Sp1 (show SP1 Proteins)- and Sp3-mediated transcription from the Dp71 (show DMD Proteins) promoter.
this study shows that YY1 regulates the formation of terminal-effector CD8 (show CD8A Proteins)+ T cell fates
that yin yang 1 strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
YY1 and SP1 (show SP1 Proteins) independently and cooperatively govern the Mesp1 (show MESP1 Proteins) expression during embryogenesis.
YY1 regulates lung CCL4 (show CCL4 Proteins) transcription in pulmonary tuberculosis.
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
YY1 transcription factor
, YY1 transcription factor, like
, transcription factor YY1
, Yin Yang 1
, INO80 complex subunit S
, Yin and Yang 1 protein
, delta transcription factor
, transcriptional repressor protein YY1
, GLI-Krupple related protein
, UCR-motif DNA-binding protein
, UCRBP transcription factor
, yin and yang 1