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Zinc Finger, CCHC Domain Containing 11 Proteins (ZCCHC11)

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011].. Additionally we are shipping Zinc Finger, CCHC Domain Containing 11 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZCCHC11 23318 Q5TAX3
ZCCHC11 230594 B2RX14
Rat ZCCHC11 ZCCHC11 313481  
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Top Zinc Finger, CCHC Domain Containing 11 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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ZCCHC11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) Interaction Partners

Human Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) interaction partners

  1. Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase (show TUT1 Proteins)) Zcchc11 (TUT4) activity.

  2. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway.

  3. miR (show MLXIP Proteins)-26a directly targets Lin28B (show LIN28B Proteins) and Zcchc11-two critical repressors of let-7 maturation.

  4. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.

  5. Lin28 (show LIN28A Proteins) uses two different TUTases to control let-7 expression .

  6. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity

  7. TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer (show DICER1 Proteins) processing. Knockdown of TUT4 and Lin28 (show LIN28A Proteins) reduces the level of stem cell markers

  8. We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (show IL22 Proteins) after LPS (show IRF6 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).

  9. Zcchc11 fine tunes IL-6 (show IL6 Proteins) production by uridylating miR (show MLXIP Proteins)-26a.

Mouse (Murine) Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) interaction partners

  1. We conclude that the Zcchc11-mediated terminal uridylation of mature miRNAs is pervasive and physiologically significant, especially important in the neonatal period for fostering IGF-1 (show IGF1 Proteins) expression and enhancing postnatal growth and survival

  2. We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA (show TIFA Proteins) after LPS (show TLR4 Proteins) treatment and suppresses the TRAF6 (show TRAF6 Proteins)-dependent activation of NF-kappaB (show NFKB1 Proteins).

  3. Zcchc11 fine tunes IL-6 (show IL6 Proteins) production by uridylating miR (show MLXIP Proteins)-26a.

  4. Lin28 (show LIN28A Proteins) recruits the TUTase (show TUT1 Proteins) Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells

Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) Protein Profile

Protein Summary

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009

Gene names and symbols associated with ZCCHC11

  • zinc finger, CCHC domain containing 11 (ZCCHC11)
  • zinc finger, CCHC domain containing 11 (zcchc11)
  • Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG5)
  • smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) (SMG5)
  • Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) (smg5)
  • terminal uridylyltransferase 4-like (LOC528986)
  • zinc finger, CCHC domain containing 11 (Zcchc11)
  • 6030404K05Rik protein
  • 9230115F04Rik protein
  • DKFZp459G145 protein
  • mKIAA0191 protein
  • PAPD3 protein
  • PPAPD3 protein
  • TUT4 protein
  • wu:fc06h08 protein
  • wu:fy37g11 protein
  • ZCCHC11 protein
  • zgc:113841 protein

Protein level used designations for ZCCHC11

zinc finger, CCHC domain containing 11 , TUTase4 , Caffeine Induced Death (S. pombe Cid) homolog family member (cid-1)-like , terminal uridylyltransferase 4-like , Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) , Est1p-like protein B , protein SMG5 , SMG5 homolog nonsense mediated mRNA decay factor , terminal uridylyltransferase 4 , PAP associated domain containing 3 , TUTase 4 , zinc finger CCHC domain-containing protein 11

GENE ID SPECIES
100294536 Pongo abelii
323683 Danio rerio
424642 Gallus gallus
456859 Pan troglodytes
100050669 Equus caballus
100141500 Xenopus (Silurana) tropicalis
100355629 Oryctolagus cuniculus
100406726 Callithrix jacchus
100484245 Ailuropoda melanoleuca
100516979 Sus scrofa
425473 Gallus gallus
457390 Pan troglodytes
490414 Canis lupus familiaris
553261 Danio rerio
100558341 Anolis carolinensis
100599356 Nomascus leucogenys
528986 Bos taurus
23318 Homo sapiens
475349 Canis lupus familiaris
230594 Mus musculus
313481 Rattus norvegicus
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