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Zinc Finger CCCH-Type Containing 12A Proteins (ZC3H12A)

ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008].. Additionally we are shipping ZC3H12A Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ZC3H12A ZC3H12A 230738 Q5D1E7
ZC3H12A 313587 A0JPN4
ZC3H12A 80149 Q5D1E8
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Top ZC3H12A Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 25 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

ZC3H12A Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,

More Proteins for Zinc Finger CCCH-Type Containing 12A (ZC3H12A) Interaction Partners

Mouse (Murine) Zinc Finger CCCH-Type Containing 12A (ZC3H12A) interaction partners

  1. Overexpression of MCPIP1 induced apoptosis.

  2. MCPIP1 is the target of mmu-miR (show MLXIP Proteins)-27-5p.

  3. MCPIP1-MSCs also expressed increased levels of proteins involved in angiogenesis, autophagy, and induction of differentiation

  4. This studies demonstrated that MCPIP1 is an important mediator of minocycline-induced protection from brain ischemia.

  5. Data indicate that MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) knockdown enhanced interleukin-17 (IL-17 (show IL17A Proteins))-mediated signaling.

  6. MCPIP expression in the ischemic myocardium protects against adverse cardiac remodeling and dysfunction following myocardial infarction

  7. both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 (show STAT6 Proteins) and KLF4 (show KLF4 Proteins) implement IL-4 (show IL4 Proteins)-induced M2 polarization via the dual catalytic activities of MCPIP.

  8. Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin (show RC3H1 Proteins) depends on their translation status and enables elaborate control of inflammation.

  9. Roquin (show RC3H1 Proteins) inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6 (show IL6 Proteins), ICOS (show ICOS Proteins), c-Rel (show NFkBP65 Proteins), IRF4 (show IRF4 Proteins), IkappaBNS (show NFKBID Proteins) and IkappaBzeta (show NFKBIZ Proteins).

  10. MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms.

Human Zinc Finger CCCH-Type Containing 12A (ZC3H12A) interaction partners

  1. Suggest that MCPIP1 may play an important role in cholesterol induced damage in endothelial cells.

  2. Findings show increased MCP1P expression in a model of Ischemia/Reperfusion Injury (I/R) and suggest a vital role for MCPIP1 in cell migration and apoptosis, resulting in increased angiogenesis and apoptosis during the late stages of I/R.

  3. In white blood cells from patients with SLE, MCPIP1 expression was elevated, and its expression correlated positively with the IFN score and negatively with the miR (show MLXIP Proteins)-146a transcript level.

  4. demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3-D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phosphoinositide 3-kinase, and NF-kappaB (show NFKB1 Proteins)

  5. In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline (show ZFP36 Proteins), Roquins, and Regnase-1.

  6. miR (show MLXIP Proteins)-139-mediated downregulation of MCPIP1 promotes IL-6 (show IL6 Proteins) expression in osteoarthritis.

  7. MCPIP1 and MCPIP4 form a complex but they act independently in regulation of IL-6 (show IL6 Proteins) mRNA degradation.

  8. Data show that regulator of G protein signaling 2 (RGS2 (show RGS2 Proteins)) was stabilized by deubiquitinase monocyte chemotactic protein-induced protein 1 (MCPIP1).

  9. MCPIP1 may suppress hepatitis C virus replication and hepatitis C virus-mediated proinflammatory responses with infection, which might contribute to the regulation of host defense against the infection and virus-induced inflammation.

  10. MCPIP1-associated USP10 (show USP10 Proteins) is essential for negative regulation of NF-kappaB (show NFKB1 Proteins) activation.

ZC3H12A Protein Profile

Protein Summary

ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.

Gene names and symbols associated with ZC3H12A

  • zinc finger CCCH-type containing 12A (ZC3H12A)
  • zinc finger CCCH type containing 12A (Zc3h12a)
  • BC036563 protein
  • dJ423B22.1 protein
  • MCPIP protein
  • MCPIP1 protein
  • RGD1306776 protein
  • RP3-423B22.1 protein

Protein level used designations for ZC3H12A

zinc finger CCCH-type containing 12A , MCP-1 treatment-induced protein , MCP-induced protein 1 , ribonuclease ZC3H12A , zinc finger CCCH domain-containing protein 12A , Zinc finger CCCH domain-containing protein 12A , MCP induced protein 1

419618 Gallus gallus
456757 Pan troglodytes
608211 Canis lupus familiaris
713604 Macaca mulatta
100395231 Callithrix jacchus
100461560 Pongo abelii
100481016 Ailuropoda melanoleuca
230738 Mus musculus
313587 Rattus norvegicus
80149 Homo sapiens
535344 Bos taurus
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