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ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008].. Additionally we are shipping ZC3H12A Antibodies (30) and many more products for this protein.
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Overexpression of MCPIP1 induced apoptosis.
MCPIP1 is the target of mmu-miR (show MLXIP Proteins)-27-5p.
MCPIP1-MSCs also expressed increased levels of proteins involved in angiogenesis, autophagy, and induction of differentiation
This studies demonstrated that MCPIP1 is an important mediator of minocycline-induced protection from brain ischemia.
Data indicate that MCPIP1 (also termed Regnase-1, encoded by Zc3h12a) knockdown enhanced interleukin-17 (IL-17 (show IL17A Proteins))-mediated signaling.
MCPIP expression in the ischemic myocardium protects against adverse cardiac remodeling and dysfunction following myocardial infarction
both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 (show STAT6 Proteins) and KLF4 (show KLF4 Proteins) implement IL-4 (show IL4 Proteins)-induced M2 polarization via the dual catalytic activities of MCPIP.
Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin (show RC3H1 Proteins) depends on their translation status and enables elaborate control of inflammation.
Roquin (show RC3H1 Proteins) inhibited T(H)17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the T(H)17 cell-promoting factors IL-6 (show IL6 Proteins), ICOS (show ICOS Proteins), c-Rel (show NFkBP65 Proteins), IRF4 (show IRF4 Proteins), IkappaBNS (show NFKBID Proteins) and IkappaBzeta (show NFKBIZ Proteins).
MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms.
Suggest that MCPIP1 may play an important role in cholesterol induced damage in endothelial cells.
Findings show increased MCP1P expression in a model of Ischemia/Reperfusion Injury (I/R) and suggest a vital role for MCPIP1 in cell migration and apoptosis, resulting in increased angiogenesis and apoptosis during the late stages of I/R.
In white blood cells from patients with SLE, MCPIP1 expression was elevated, and its expression correlated positively with the IFN score and negatively with the miR (show MLXIP Proteins)-146a transcript level.
demonstrated induction of MCPIP1 in human fibroblasts embedded in the stress-released 3-D collagen matrix, which occurred through activation of mitogen-activated protein kinases, phosphoinositide 3-kinase, and NF-kappaB (show NFKB1 Proteins)
In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline (show ZFP36 Proteins), Roquins, and Regnase-1.
miR (show MLXIP Proteins)-139-mediated downregulation of MCPIP1 promotes IL-6 (show IL6 Proteins) expression in osteoarthritis.
MCPIP1 and MCPIP4 form a complex but they act independently in regulation of IL-6 (show IL6 Proteins) mRNA degradation.
Data show that regulator of G protein signaling 2 (RGS2 (show RGS2 Proteins)) was stabilized by deubiquitinase monocyte chemotactic protein-induced protein 1 (MCPIP1).
MCPIP1 may suppress hepatitis C virus replication and hepatitis C virus-mediated proinflammatory responses with infection, which might contribute to the regulation of host defense against the infection and virus-induced inflammation.
MCPIP1-associated USP10 (show USP10 Proteins) is essential for negative regulation of NF-kappaB (show NFKB1 Proteins) activation.
ZC3H12A is an MCP1 (CCL2\; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.
zinc finger CCCH-type containing 12A
, MCP-1 treatment-induced protein
, MCP-induced protein 1
, ribonuclease ZC3H12A
, zinc finger CCCH domain-containing protein 12A
, Zinc finger CCCH domain-containing protein 12A
, MCP induced protein 1