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Involved in transcriptional regulation. Additionally we are shipping Zinc Finger Protein 148 Antibodies (55) and many more products for this protein.
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A larger role ZBP-89 plays in gene regulation during inflammation.ZBP-89 regulates of MMP-1 (show MMP1 Proteins) expression.ZBP-89 and NF-kappaB (show NFKB1 Proteins) appear to bind cooperatively on both promoters.
ZBP-89 attenuates HDAC3 (show HDAC3 Proteins) by increasing IkappaB degradation, dependent on Pin1 (show PIN1 Proteins) but independent of NF-Kappab (show NFKB1 Proteins)
zinc-binding protein-89 upregulates the expression of Bak (show BAK1 Proteins) by targeting multiple components of the epigenetic pathway in hepatocellular carcinoma.
lower expression of ZNF148 in colorectal cancer was significantly associated with worse clinicopathologic variables, including lymph node metastases, poor differentiation, and a higher rate of disease recurrence
this study provides vigorous evidence that ZBP-89 was significantly downregulated in clear cell renal cell carcinoma (show MOK Proteins)(CCRCC) and could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC.
Colony formation was reduced dramatically in those hepatocellular carcinoma cell lines in which ZBP-89 overexpression was demonstrated; this appeared to correlate with increased apoptosis.
We found that the TP53 (show TP53 Proteins)-G245D variant but not TP53 (show TP53 Proteins)-R249S abrogated HDAC (show HDAC3 Proteins) inhibitor p21 (show CDKN1A Proteins) induction by binding to ZBP-89 and retaining it in the cytoplasm.
ZBP-89 is a regulator of Pdcd4 (show PDCD4 Proteins) gene, binding to the basal promoter either alone or by interacting with Sp family members.
An activating role for ZBP-89 in human globin gene regulation and erythroid differentiation.
Alternative binding of ZBP89 or SP1 (show PSG1 Proteins) to the described region in the IRS2 (show IRS2 Proteins) promoter regulates neuronal IRS2 (show IRS2 Proteins) expression in a PI3K (show PIK3CA Proteins)-dependent manner.
Zfp148 deficiency increases p53 (show TP53 Proteins) activity and protects against atherosclerosis by causing proliferation arrest of lesional macrophages.
These data identify an important role for ZBP-89 in regulating stress hematopoiesis in adult mouse bone marrow.
Results indicate that Zfp148-deficient mice generate normal mature hematopoietic populations.
Zfp148 deficiency causes lung maturation defects and lethality.
ZBP-89 is required for expression of the Tph1 (show TPH1 Proteins) gene and subsequent production of 5HT (show DDC Proteins) in response to bacterial infection in mice. Reductions in epithelial ZBP-89 increase susceptibility to colitis and sepsis after infection with S. typhimurium.
MiR-203 expression downregulated ZFP-148 mRNA translation by specifically targeting its 3' UTR, which resulted in differential expression of its downstream target genes, which in turn promote cell survival to foster Coxsackievirus B3 replication
ataxia telangiectasia mutated (show ATM Proteins) protein phosphorylation of ZBP-89 contributes to Histone deacetylase (show HDAC1 Proteins) inhibitors induction of p21(waf1 (show CDKN1A Proteins)) gene expression
identify ZBP-89 as being a novel transcription factor involved in erythroid and megakaryocytic development and suggest that it serves a cooperative function with GATA-1 (show GATA1 Proteins) and/or FOG-1 (show ZFPM1 Proteins) in a developmental stage-specific manner
The transcriptional repressor ZBP-89 and the lack of Sp1 (show SP1 Proteins)/Sp3, c-jun (show JUN Proteins) and Stat3 (show STAT3 Proteins) are important for the down-regulation of the vimentin (show VIM Proteins) gene during C2C12 myogenesis.
the G(5) string is necessary for Gata1 (show GATA1 Proteins) gene expression in vivo and ZBP-89 is the functional trans-acting factor for this cis (show CISH Proteins)-acting region.
Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.
CACCC box-binding protein
, CLL-associated antigen KW-10
, transcription factor ZBP-89
, zinc finger DNA-binding protein 89
, G-rich box-binding protein
, beta enolase repressor factor 1
, transcription factor BFCOL1
, zinc finger binding protein 89
, zinc finger DNA binding protein 89
, solute carrier family 12 (potassium/chloride transporters), member 8
, zinc finger protein 148 (pHZ-52)