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ZBTB33 encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Additionally we are shipping ZBTB33 Antibodies (33) and ZBTB33 Kits (2) and many more products for this protein.
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Dyrk1A (show DYRK1A Proteins) positively and selectively modulates p120-catenin (show CTNND1 Proteins) protein levels, thus having an impact on p120-catenin (show CTNND1 Proteins) and Kaiso (and canonical Wnt (show WNT2 Proteins)) gene targets such as siamois and wnt11.
xKaiso plays an essential role as a global repressor of methylated genes during early vertebrate development.
propose that mutual inhibition by Kaiso/TCF3 (show TCF3 Proteins) of their DNA-binding functions may be important in developmental or cancer contexts and acts as a regulatory node that integrates epigenetic and Wnt (show WNT2 Proteins) signalling pathways
The major phenotypic defects associated with xKaiso depletion are premature transcription activation before the mid-blastula transition and concomitant activation of a p53 (show TP53 Proteins)-dependent cell-death pathway
Kaiso is a bimodal modulator for Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling.
Kaiso modulates HIF1A (show HIF1A Proteins) gene expression by binding to the methylated HIF1A (show HIF1A Proteins) promoter in a region proximal to the autoregulatory HIF-1 (show HIF1A Proteins) binding site, primarily during hypoxia.
NF-kappaB (show NFKB1 Proteins) response element, located close to the p53RE#1, mediates APAF1 (show APAF1 Proteins) transcriptional repression by affecting interaction between KAISO and p53 (show TP53 Proteins)
KAISO is a regulator of p53 (show TP53 Proteins)-mediated transcription of CDKN1A and apoptotic genes
Data indicate that Kaiso protein participates in the regulation of beta-catenin (show CTNNB1 Proteins) mRNA expression by interacting with p120-catenin (show CTNND1 Proteins) in the lung cancer cell lines.
Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT (show ITK Proteins) in infiltrating ductal carcinomas.
The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling.
Transcription factor Kaiso does not interact with hydroxymethylated DNA within CTGCNA sequence context
presence of MTG16 (show CBFA2T3 Proteins) in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16 (show CBFA2T3 Proteins)-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression
Kaiso represses the cell cycle gene cyclin D1 (show CCND1 Proteins) via sequence-specific and methyl-CpG-dependent mechanism.
These findings establish a defined oncogenic role of Kaiso in promoting the progression of prostate cancer.
Kaiso and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.
Study revealed the involvement of the Zbtb33 gene and, probably, the Kaiso protein in the regulation of locomotion and brain morphology in mice
a mechanistic link between E-cadherin (show CDH1 Proteins) loss and subsequent control of Rho-driven anoikis resistance through p120 (show CTNND1 Proteins)- and Kaiso-dependent expression of Wnt11 (show WNT11 Proteins), is reported.
S100A3 (show S100A3 Proteins) is a new target gene of Kaiso in mouse skin
ZBTB33 expression may elicit intestinal inflammation by antagonizing p120ctn (show CTNND1 Proteins) function.
derepressed Bcl6 (show BCL6 Proteins) expression may be responsible for increases in germinal centers cell proliferation and splenomegaly of Kaiso knockout mice.
KAISO, similar to SMRT, accelerates the cell cycle and increases fat accumulation upon knockdown, identifying KAISO as an adipogenic repressor that likely modulates the mitotic clonal expansion phase of this process.
Znf131 (show ZNF131 Proteins) is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso.
These results provide the first experimental evidence that rapsyn (show RAPSN Proteins) is a direct sequence-specific target of Kaiso and delta-catenin (show CTNND2 Proteins).
p120-catenin (show CTNND1 Proteins) and Kaiso are essential components of a new developmental gene regulatory pathway that controls vertebrate morphogenesis.
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA-methylation dependent transcriptional repressor Kaiso-like protein
, transcriptional regulator Kaiso
, zinc finger and BTB domain-containing protein 33
, kaiso transcription factor
, zinc finger transcription factor Kaiso