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Zona Pellucida Glycoprotein 2 Proteins (ZP2)

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. Additionally we are shipping ZP2 Antibodies (15) and ZP2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse ZP2 ZP2 22787 P20239
ZP2 7783 Q05996
ZP2 81828 O54767
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Top ZP2 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,853.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ZP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

More Proteins for Zona Pellucida Glycoprotein 2 (ZP2) Interaction Partners

Zebrafish Zona Pellucida Glycoprotein 2 (ZP2) interaction partners

Mouse (Murine) Zona Pellucida Glycoprotein 2 (ZP2) interaction partners

  1. ZP2(51-149) sperm-binding domain is necessary for mouse gamete recognition and penetration through the zona pellucida.

  2. Studies indicate that eggs from mZP2-/- and mZP3-/- females lack a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts.

  3. Sperm arylsulfatase A (show ARSA Proteins) binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner.

  4. Recombinant ovastacin cleaved ZP2 in native zonae pellucidae, documenting that ZP2 was a direct substrate of this metalloendoprotease.

  5. Cytoplasmic tails are necessary to prevent intracellular oligomerization while ensuring incorporation of processed ZP2 and ZP3 (show ZP3 Proteins) into the zona pellucida.

  6. data indicate that sperm-egg recognition depends on the cleavage status of ZP2 and that binding at the surface of the zona is not sufficient to induce sperm acrosome exocytosis

  7. stoichiometric disposition of ZP1 (show ZP1 Proteins), ZP2, and ZP3 (show ZP3 Proteins) in the ovarian zona matrix revealed by double and triple immunolocalization studies

  8. Results indicate that ZP2 and ZP3 (show ZP3 Proteins) traffic independently through the oocyte prior to assembly into the zona pellucida.

Human Zona Pellucida Glycoprotein 2 (ZP2) interaction partners

  1. ZP2(51-149) sperm-binding domain is necessary for human gamete recognition and penetration through the zona pellucida.

  2. Studies indicate that eggs from mice lacking an ortholog of ZP2 do not contain a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts.

  3. observed sequence variations in exons of ZP2 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS]

  4. Of all zona pellucida (ZP) proteins, recombinant human ZPA demonstrates the highest binding activity toward acrosin (show ACR Proteins)

Cow (Bovine) Zona Pellucida Glycoprotein 2 (ZP2) interaction partners

  1. Polymorphism of Zp2 and the Zp3 (show ZP3 Proteins) did not show any contribution to reproductive isolation between the bovine species.

ZP2 Protein Profile

Protein Summary

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

Gene names and symbols associated with ZP2

  • zona pellucida glycoprotein 2, tandem duplicate 1 (zp2.1)
  • zona pellucida glycoprotein 2 (Zp2)
  • zona pellucida glycoprotein 2 (sperm receptor) (ZP2)
  • zona pellucida glycoprotein 2 (sperm receptor) (Zp2)
  • fa12e07 protein
  • wu:fa12e07 protein
  • zgc:152728 protein
  • Zp-2 protein
  • zp2 protein
  • ZPA protein

Protein level used designations for ZP2

zona pellucida glycoprotein ZP2 , zona pellucida protein A , zona pellucida sperm-binding protein 2 , zona pellucida A protein , ZP1 , zona pellucida 2 glycoprotein , 75-kDa rabbit zona pellucida protein

GENE ID SPECIES
30593 Danio rerio
22787 Mus musculus
7783 Homo sapiens
403988 Canis lupus familiaris
396846 Sus scrofa
280963 Bos taurus
100009069 Oryctolagus cuniculus
81828 Rattus norvegicus
493977 Felis catus
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