delta-Like 1 Homolog (Drosophila) Proteins (DLK1)

DLK1 encodes a transmembrane protein containing six epidermal growth factor repeats. Additionally we are shipping DLK1 Antibodies (180) and DLK1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLK1 8788 P80370
DLK1 13386 Q09163
Rat DLK1 DLK1 114587  
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Top DLK1 Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_HEK-293 Cells Mouse Fc Tag   10 μg Log in to see 5 to 8 Days
$299.25
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HOST_HEK-293 Cells Human Fc Tag   10 μg Log in to see 5 to 8 Days
$309.75
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HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
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HOST_HEK-293 Cells Human DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$299.25
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HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details

DLK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
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Mouse (Murine) ,
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More Proteins for delta-Like 1 Homolog (Drosophila) (DLK1) Interaction Partners

Cow (Bovine) delta-Like 1 Homolog (Drosophila) (DLK1) interaction partners

  1. DLK1 mRNA expression in mesenteric fat was higher than subcutaneous fat. DLK1 mRNA expression in Holstein cattle mesenteric fat was higher than Wagyu cattle.

  2. The four loci of DLK1 gene and CLPG gene in 1109 individuals, which belong to eight breeds/species of bovidae, including cattle, buffalo and yak, were analyzed.

  3. tissue-specific expression patterns of Dlk-1 splice variants in bovine tissues

Human delta-Like 1 Homolog (Drosophila) (DLK1) interaction partners

  1. SASH1 (show SASH1 Proteins) acts through NOTCH1 (show NOTCH1 Proteins) and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1 (show CEACAM1 Proteins).

  2. The data presented in this work suggest that a fine regulation of NOTCH (show NOTCH1 Proteins) signaling BY DLK1 plays an important role in the control of breast cancer cell proliferation and invasion.

  3. results demonstrate that miR (show MLXIP Proteins)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1

  4. A complex defect of DLK1 ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1, including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1.

  5. Loss of DLK1 expression is associated with fetal growth retardation complications of pregnancy.

  6. In neonatal skin, DLK1 exhibited a high degree of monoallelic expression from the paternal allele.

  7. The study evaluated the roles of extracellular soluble DLK1, comprising six EGF (show EGF Proteins)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (show MIA Proteins) PaCa-2 cells in vitro and in vivo. Soluble DLK1 exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.

  8. Treatment of mice with recombinant human DLK1 during pregnancy has significant effects on AT of the offspring. This can be associated with counter-regulatory changes in the Notch1 (show NOTCH1 Proteins) signaling cascade.

  9. NOTCH1 (show NOTCH1 Proteins) ligand Delta-like 1 (show DLL1 Proteins) homolog (DLK1) self interacts

  10. Pref-1 induces insulin (show INS Proteins) synthesis and secretion via two independent pathways

Pig (Porcine) delta-Like 1 Homolog (Drosophila) (DLK1) interaction partners

  1. trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.

  2. We did not observe significantly different expression of DLK1, MEG3 or PEG11 mRNA in any of analyzed breeds.

  3. QUASEP supports paternal expression of DLK1 in whole brain, carcass, liver and placental tissues of day 30 interbreed porcine fetuses.

  4. the sequence of porcine DLK1 (pDLK1)was examined,the expression and alternative splicing isoforms in the pig (Sus scrofa) was compared with human

  5. Polymorphisms, imprinting status and quantitative trait locus analyses of the porcine DLK1 and MEG3 genes i swine.

  6. Expression of DLK1 splice variants during adipocyte development in vitro and in vivo.

Mouse (Murine) delta-Like 1 Homolog (Drosophila) (DLK1) interaction partners

  1. The role of elevated oxygen levels in eroding imprinted Dlk1 expression during prolonged culture and in vitro differentiation.

  2. Loss of DLK1 expression is associated with fetal growth retardation complications of pregnancy.

  3. Pref-1 mRNA is a novel substrate of RNase-L (show RNASEL Proteins).

  4. the conserved sequences in IG-DMR (show WDR20 Proteins) are involved in the expression regulation of some of the imprinted genes in the Dlk1-Dio3 (show DIO3 Proteins) domain

  5. To investigate the nature of these more variably methylated secondary differentially methylated regions, we adopted a hairpin linker bisulfite mutagenesis approach to examine CpG dyad methylation at differentially methylated regions associated with the murine Dlk1/Gtl2 imprinting cluster on both complementary strands.

  6. NOTCH1 (show NOTCH1 Proteins) ligand Delta-like 1 (show DLL1 Proteins) homolog (DLK1) self interacts

  7. the salivary gland phenotype of Dlk1 knock-out mice, was investigated.

  8. The brain-specific (show CALY Proteins) miR (show MLXIP Proteins)-379/miR (show MLXIP Proteins)-410 gene cluster at the imprinted Dlk1-Dio3 (show DIO3 Proteins) domain is implicated in several aspects of brain development and function.

  9. data provide the first evidence for a direct interaction between DLK1 and NOTCH1 (show NOTCH1 Proteins) in mammals, and substantiate that non-canonical NOTCH (show NOTCH1 Proteins) ligands exist, adding to the complexity of NOTCH (show NOTCH1 Proteins) signaling.

  10. the Dlk1-Gtl2 locus plays a critical role in preserving long-term repopulating HSCs (LT-HSCs).

DLK1 Protein Profile

Protein Summary

This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes\; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance\; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Gene names and symbols associated with DLK1

  • delta-like 1 homolog (Drosophila) (DLK1)
  • delta-like 1 homolog (Drosophila) (Dlk1)
  • AW742678 protein
  • Delta1 protein
  • DLK protein
  • DLK-1 protein
  • DlkI protein
  • FA1 protein
  • Ly107 protein
  • Peg9 protein
  • pG2 protein
  • pref-1 protein
  • PREF1 protein
  • SCP1 protein
  • Zog protein

Protein level used designations for DLK1

delta-like homolog , preadipocyte factor-1 , protein delta homolog 1 , delta-like 1 homolog (Drosophila) , delta-like protein 1 , protein delta homolog 1-like , fetal antigen 1 , preadipocyte factor 1 , secredeltin , adipocyte differentiation inhibitor protein , stromal cell derived protein 1

GENE ID SPECIES
281117 Bos taurus
423459 Gallus gallus
490860 Canis lupus familiaris
707595 Macaca mulatta
100054933 Equus caballus
100082485 Ornithorhynchus anatinus
100303692 Meleagris gallopavo
100449207 Pongo abelii
100598289 Nomascus leucogenys
8788 Homo sapiens
497066 Sus scrofa
13386 Mus musculus
114587 Rattus norvegicus
641301 Ovis aries
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