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phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) ELISA Kits

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Additionally we are shipping PIKFYVE Antibodies (70) and PIKFYVE Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PIKFYVE 200576 Q9Y2I7
PIKFYVE 18711 Q9Z1T6
PIKFYVE 316457  
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Top PIKFYVE ELISA Kits at antibodies-online.com

Showing 2 out of 14 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 2 to 3 Days
$380.00
Details
Rat
96 Tests Log in to see 11 to 13 Days
$785.71
Details

More ELISA Kits for PIKFYVE Interaction Partners

Zebrafish phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. Cloning of pip5k3 and report on its molecular characterization and expression pattern in adult fish as well as during development.

Human phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. A novel heterozygous frameshift mutation (c.3151dupA) and a copy number variations in PIKFYVE gene have been found in two unrelated Fleck corneal dystrophy patients.

  2. The PIKfyve complex is required for APP (show APP ELISA Kits) trafficking, suggesting a feedback loop in which APP (show APP ELISA Kits), by binding to and stimulating phosphatidylinositol-3,5-bisphosphate vesicle formation may control its own trafficking.

  3. APP (show APP ELISA Kits) functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function.

  4. data identify a novel role of the ArPIKfyve-Sac3 complex in the mechanisms controlling aggregate formation of Sph1 and suggest that Sac3 protein deficiency or overproduction may facilitate aggregation of aggregation-prone proteins

  5. Data suggest PIKFYVE, MTMR3 (myotubularin related protein 3 (show MTMR3 ELISA Kits)) and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein (show ARF3 ELISA Kits)); this process regulates migration/invasion of carcinoma/sarcoma.

  6. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 ELISA Kits), which is necessary and sufficient for suppression of type I IFN expression.

  7. Data indicate that AKT (show AKT1 ELISA Kits) promotes EGFR (show EGFR ELISA Kits) recycling by phosphorylating and activating PIKfyve.

  8. the present observations show that PKB (show AKT1 ELISA Kits) in conjunction with PIKfyve activates Kir2.1 (show KCNJ2 ELISA Kits) channels.

  9. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 (show MTMR3 ELISA Kits) regulates cell migration.

  10. PIP5Kalpha promotes TLR4 (show TLR4 ELISA Kits)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP ELISA Kits) to the plasma membrane

Mouse (Murine) phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. adipose tissue Pikfyve plays a key role in the mechanisms regulating glucose homeostasis and the PIKfyve pathway is critical in mammary epithelial differentiation during pregnancy and lactogenesis downstream of prolactin receptor (show PRLR ELISA Kits) signaling.

  2. AP-3 (show AP3B1 ELISA Kits) recruitment to TLR9 (show TLR9 ELISA Kits) endosomes was impaired by PIKfyve inhibition.

  3. PIKfyve mediates vesicle motility through the regulation of vesicle integrity in neurons.

  4. Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

  5. Vps34 (show PIK3C3 ELISA Kits) is a main phosphatidylinositol 3-phosphate source for constitutive PIKfyve functionality.

  6. Daam2-PIP5K function, application of which stimulates remyelination after white matter injury

  7. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 ELISA Kits), which is necessary and sufficient for suppression of type I IFN expression.

  8. PIP5Kbeta negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in DRG neurons.

  9. PIKfyve is essential for systemic glucose homeostasis and insulin (show INS ELISA Kits)-regulated glucose uptake/GLUT4 (show SLC2A4 ELISA Kits) translocation in skeletal muscle.

  10. PIP5Kalpha promotes TLR4 (show TLR4 ELISA Kits)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP ELISA Kits) to the plasma membrane

PIKFYVE Antigen Profile

Antigen Summary

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PIKFYVE

  • phosphoinositide kinase, FYVE finger containing (pikfyve) antibody
  • phosphoinositide kinase, FYVE finger containing (PIKFYVE) antibody
  • phosphoinositide kinase, FYVE finger containing (Pikfyve) antibody
  • 5230400C17Rik antibody
  • CFD antibody
  • FAB1 antibody
  • fab1-like antibody
  • p235 antibody
  • Pip5k antibody
  • Pip5k3 antibody
  • Pipk5k3 antibody
  • PipkIII antibody
  • wu:fo93c03 antibody
  • ZFYVE29 antibody

Protein level used designations for PIKFYVE

1-phosphatidylinositol-3-phosphate 5-kinase , phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III , 1-phosphatidylinositol 3-phosphate 5-kinase , PIPkin-III , phosphatidylinositol 3-phosphate 5-kinase type III , type III PIP kinase , zinc finger, FYVE domain containing 29 , FYVE finger-containing phosphoinositide kinase , PtdIns(4)P-5-kinase , phosphatidylinositol-3-phosphate 5-kinase type III , phosphatidylinositol-4-phosphate 5-kinase, type III

GENE ID SPECIES
337690 Danio rerio
424114 Gallus gallus
459908 Pan troglodytes
478890 Canis lupus familiaris
790873 Bos taurus
200576 Homo sapiens
18711 Mus musculus
316457 Rattus norvegicus
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