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PIKFYVE Products

(phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE))

Categories

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].

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Featured PIKFYVE Categories

PIKFYVE Antibodies

High quality antibodies with extensive validation data.

PIKFYVE ELISA Kits

Reliable ELISA kits for a wide range of species.

PIKFYVE Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PIKFYVE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IF, IHC (p), RNAi
Validations
  • (2)
  • (6)
Cat. No. ABIN566937
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN7011299
Quantity 60 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN391254
Quantity 400 μL
Datasheet Datasheet

Recommended PIKFYVE ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381425
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1773394
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774618
Quantity 96 tests
Datasheet Datasheet

Recommended PIKFYVE Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315147
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315149
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405229
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PIKFYVE products

Takasuga, Horie, Sasaki, Sun-Wada, Kawamura, Iizuka, Mizuno, Eguchi, Kofuji, Kimura, Yamazaki, Horie, Odanaga, Sato, Chida, Kontani, Harada, Katada, Suzuki, Wada, Ohnishi, Sasaki: "Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 5, pp. 1726-31, (2013) (PubMed).

Alesutan, Ureche, Laufer, Klaus, Zürn, Lindner, Strutz-Seebohm, Tavaré, Boehmer, Palmada, Lang, Seebohm, Lang: "Regulation of the glutamate transporter EAAT4 by PIKfyve." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 25, Issue 2-3, pp. 187-94, (2010) (PubMed).

Tsuruta, Green, Rousset, Dolmetsch: "PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death." in: The Journal of cell biology, Vol. 187, Issue 2, pp. 279-94, (2009) (PubMed).

Yang, Carpenter, Abrams: "Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 42331-6, (2004) (PubMed).

Sbrissa, Ikonomov, Strakova, Dondapati, Mlak, Deeb, Silver, Shisheva: "A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity." in: Molecular and cellular biology, Vol. 24, Issue 23, pp. 10437-47, (2004) (PubMed).

Ikonomov, Sbrissa, Mlak, Deeb, Fligger, Soans, Finley, Shisheva: "Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50863-71, (2003) (PubMed).

Sbrissa, Ikonomov, Deeb, Shisheva: "Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47276-84, (2002) (PubMed).

Synonyms and alternative names related to PIKFYVE

phosphoinositide kinase, FYVE finger containing (pikfyve), phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE), phosphoinositide kinase, FYVE type zinc finger containing (Pikfyve), phosphoinositide kinase, FYVE-type zinc finger containing (Pikfyve), 5230400C17Rik, CFD, FAB1, fab1-like, p235, PIP5K, Pip5k, pip5k3, PIP5K3, Pip5k3, Pipk5k3, PipkIII, wu:fo93c03, ZFYVE29

Protein level used designations for PIKFYVE

  • 1-phosphatidylinositol-3-phosphate 5-kinase
  • phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
  • 1-phosphatidylinositol 3-phosphate 5-kinase
  • PIPkin-III
  • phosphatidylinositol 3-phosphate 5-kinase type III
  • type III PIP kinase
  • zinc finger, FYVE domain containing 29
  • FYVE finger-containing phosphoinositide kinase
  • PtdIns(4)P-5-kinase
  • phosphatidylinositol-3-phosphate 5-kinase type III
  • phosphatidylinositol-4-phosphate 5-kinase, type III
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