You are viewing an incomplete version of our website. Please click to reload the website as full version.

phosphoinositide Kinase, FYVE Finger Containing Proteins (PIKFYVE)

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Additionally we are shipping PIKFYVE Antibodies (69) and PIKFYVE Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIKFYVE 200576 Q9Y2I7
PIKFYVE 18711 Q9Z1T6
Rat PIKFYVE PIKFYVE 316457  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top PIKFYVE Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$735.90
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$434.28
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PIKFYVE Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,

Mouse (Murine)

More Proteins for phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) Interaction Partners

Zebrafish phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. Cloning of pip5k3 and report on its molecular characterization and expression pattern in adult fish as well as during development.

Human phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. A novel heterozygous frameshift mutation (c.3151dupA) and a copy number variations in PIKFYVE gene have been found in two unrelated Fleck corneal dystrophy patients.

  2. The PIKfyve complex is required for APP (show APP Proteins) trafficking, suggesting a feedback loop in which APP (show APP Proteins), by binding to and stimulating phosphatidylinositol-3,5-bisphosphate vesicle formation may control its own trafficking.

  3. APP (show APP Proteins) functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function.

  4. data identify a novel role of the ArPIKfyve (show VAC14 Proteins)-Sac3 (show MCM3AP Proteins) complex in the mechanisms controlling aggregate formation of Sph1 and suggest that Sac3 (show MCM3AP Proteins) protein deficiency or overproduction may facilitate aggregation of aggregation-prone proteins

  5. Data suggest PIKFYVE, MTMR3 (myotubularin related protein 3 (show MTMR3 Proteins)) and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein (show ARF3 Proteins)); this process regulates migration/invasion of carcinoma/sarcoma.

  6. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 Proteins), which is necessary and sufficient for suppression of type I IFN expression.

  7. Data indicate that AKT (show AKT1 Proteins) promotes EGFR (show EGFR Proteins) recycling by phosphorylating and activating PIKfyve.

  8. the present observations show that PKB (show AKT1 Proteins) in conjunction with PIKfyve activates Kir2.1 (show KCNJ2 Proteins) channels.

  9. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 (show MTMR3 Proteins) regulates cell migration.

  10. PIP5Kalpha promotes TLR4 (show TLR4 Proteins)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP Proteins) to the plasma membrane

Mouse (Murine) phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) interaction partners

  1. adipose tissue Pikfyve plays a key role in the mechanisms regulating glucose homeostasis and the PIKfyve pathway is critical in mammary epithelial differentiation during pregnancy and lactogenesis downstream of prolactin receptor (show PRLR Proteins) signaling.

  2. AP-3 (show AP3B1 Proteins) recruitment to TLR9 (show TLR9 Proteins) endosomes was impaired by PIKfyve inhibition.

  3. PIKfyve mediates vesicle motility through the regulation of vesicle integrity in neurons.

  4. Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

  5. Vps34 (show PIK3C3 Proteins) is a main phosphatidylinositol 3-phosphate source for constitutive PIKfyve functionality.

  6. Daam2-PIP5K function, application of which stimulates remyelination after white matter injury

  7. Data indicate that pharmacological or genetic inactivation of PIKfyve rapidly induces expression of the transcription repressor ATF3 (show ATF3 Proteins), which is necessary and sufficient for suppression of type I IFN expression.

  8. PIP5Kbeta negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in DRG neurons.

  9. PIKfyve is essential for systemic glucose homeostasis and insulin (show INS Proteins)-regulated glucose uptake/GLUT4 (show SLC2A4 Proteins) translocation in skeletal muscle.

  10. PIP5Kalpha promotes TLR4 (show TLR4 Proteins)-associated microglial inflammation by mediating PIP(2)-dependent recruitment of TIRAP (show TIRAP Proteins) to the plasma membrane

PIKFYVE Protein Profile

Protein Summary

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PIKFYVE

  • phosphoinositide kinase, FYVE finger containing (pikfyve)
  • phosphoinositide kinase, FYVE finger containing (PIKFYVE)
  • phosphoinositide kinase, FYVE finger containing (Pikfyve)
  • 5230400C17Rik protein
  • CFD protein
  • FAB1 protein
  • fab1-like protein
  • p235 protein
  • Pip5k protein
  • Pip5k3 protein
  • Pipk5k3 protein
  • PipkIII protein
  • wu:fo93c03 protein
  • ZFYVE29 protein

Protein level used designations for PIKFYVE

1-phosphatidylinositol-3-phosphate 5-kinase , phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III , 1-phosphatidylinositol 3-phosphate 5-kinase , PIPkin-III , phosphatidylinositol 3-phosphate 5-kinase type III , type III PIP kinase , zinc finger, FYVE domain containing 29 , FYVE finger-containing phosphoinositide kinase , PtdIns(4)P-5-kinase , phosphatidylinositol-3-phosphate 5-kinase type III , phosphatidylinositol-4-phosphate 5-kinase, type III

GENE ID SPECIES
337690 Danio rerio
424114 Gallus gallus
459908 Pan troglodytes
478890 Canis lupus familiaris
790873 Bos taurus
200576 Homo sapiens
18711 Mus musculus
316457 Rattus norvegicus
Selected quality suppliers for PIKFYVE Proteins (PIKFYVE)
Did you look for something else?