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Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Additionally we are shipping PIK3AP1 Proteins (7) and PIK3AP1 Kits (4) and many more products for this protein.
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Human Polyclonal PIK3AP1 Primary Antibody for EIA, WB - ABIN954143
Koutros, Schumacher, Hayes, Ma, Huang, Albanes, Canzian, Chanock, Crawford, Diver, Feigelson, Giovanucci, Haiman, Henderson, Hunter, Kaaks, Kolonel, Kraft, Le Marchand, Riboli, Siddiq, Stampfer, Stram, Thomas, Travis, Thun, Yeager, Berndt: Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. in Cancer research 2010
Show all 5 references for ABIN954143
Abi-1 (show ABI1 Antibodies) promotes Abl (show ABL1 Antibodies)-mediated BCAP (show PHF11 Antibodies) phosphorylation and suggest that Abi-1 (show ABI1 Antibodies) in general coordinates kinase-substrate interactions
Nck (show NCK1 Antibodies)-mediated recruitment of BCAP to the BCR (show BCR Antibodies) regulates the PI(3 (show PI3 Antibodies))K-Akt (show AKT1 Antibodies) pathway in B cells.
BCAP is an essential activator of the PI3K pathway downstream of TLR signaling.
BCAP is a unique TIR domain-containing toll (show TLR4 Antibodies) like receptor (TLR) signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response.
As macrophages engage their pathogenic targets, innate immune receptors trigger increased expression of BCAP, which endows them with the capacity to withstand further challenges from ongoing cellular insults, such as endoplasmic reticulum stress.
BCAP-(L) (but not BCAP-(S)) is a negative regulator of the TLR-mediated host defense system in macrophages.
BCAP and CD19 have complementary roles in BCR-mediated phosphoinositide 3-kinase activation
model in which blunting of BCAP-mediated activation signaling in developing NK cells promotes functionality, terminal maturation, and long-term survival
Involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B-cells via activation of REL (By similarity).
B cell adaptor protein
, B-cell adapter for phosphoinositide 3-kinase
, B-cell phosphoinositide 3-kinase adapter protein 1
, phosphoinositide 3-kinase adapter protein 1
, B cell phosphoinositide 3-kinase adaptor