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SPINK5 encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal SPINK5 Primary Antibody for EIA, WB - ABIN453393
Nin, Katoh, Kokura, Handa, Yoshikawa, Kishimoto: Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes. in Journal of dermatological science 2009
Human Polyclonal SPINK5 Primary Antibody for ICC, IF - ABIN4355707
McGovern, Meinert, de Veer, Hollier, Parker, Upton: Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. in The British journal of dermatology 2016
This report discloses a prevalent SPINK5 founder mutation in Finland and illustrates Netherton syndrome phenotype variability
New mutation leading to the full variety of typical features of the Netherton syndrome.
The results suggest that SPINK5 and ADRB2 (show ADRB2 Antibodies) haplotypes might play a role in the susceptibility to childhood-onset asthma
The effect of GATA3 on SPINK5 expression was indirect and GATA3 alone was insufficient for final differentiation of keratinocytes where full SPINK5 expression was observed.
these results support epistasis between SPINK5 and TSLP (show TSLP Antibodies), which contributes to childhood asthma.
Netherton syndrome is caused by mutations in SPINK5, which encodes the serine protease inhibitor LEKTI.
Herein we report three patients with Netherton syndrome who had growth retardation associated with GH deficiency and responded well to GH therapy.
mesotrypsin (show PRSS3 Antibodies) contributes to the desquamation process by activating KLKs and degrading the intrinsic KLKs' inhibitor LEKTI
The E420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation.
major binding partners of LEKTI were found to be the antimicrobial peptide (show cAMP Antibodies) dermcidin (show DCD Antibodies) and the serine protease (show F2 Antibodies) cathepsin G (show CTSG Antibodies) and no kallikreins.
Spink5/Par2 (show F2RL1 Antibodies) double knockout (DKO) mice, at embryonic day 19.5, display a dramatic decrease in TSLP (show TSLP Antibodies) expression, although stratum corneum detachment persists, confirming the role of the KLK5-PAR2 (show F2RL1 Antibodies) cascade in TSLP (show TSLP Antibodies)-mediated early proallergic signaling
Mouse Spink5/Lekti, like its human counterpart, is involved in the control of epithelial tissue homeostasis.
This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene.
serine protease inhibitor, Kazal type 5
, lympho-epithelial Kazal-type-related inhibitor
, lymphoepithelial Kazal-type-related inhibitor
, serine protease inhibitor Kazal-type 5
, Netherton syndrome