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Serine/threonine protein kinase which phosphorylates VIME. Additionally we are shipping STK33 Antibodies (117) and many more products for this protein.
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STK33 is a potential oncogene (show RAB1A Proteins) and plays an important role in tumorigenesis of HSCC via regulation of numerous genes.
STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc (show MYC Proteins) and increase its transcriptional activity.
Results show that STK33 is a potential oncogene (show RAB1A Proteins) and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC.
STK33 can promote cell migration and invasion and suppress p53 (show TP53 Proteins) gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition.
The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.
STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells.
STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group
Double-immunostaining experiments with antibodies against Stk33 and vimentin (show VIM Proteins) showed a striking colocalization of Stk33 and vimentin (show VIM Proteins) in the hypothalamus.
STK33 promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells.
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity).
serine/threonine-protein kinase 33