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Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Additionally we are shipping tau Tubulin Kinase 1 Antibodies (61) and many more products for this protein.
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TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 (show TARDBP Proteins) proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.
X-ray diffraction data were collected and the structure of TTBK1 was determined by molecular replacement both as an apo (show C9orf3 Proteins) structure and in complex with a kinase inhibitor
The study suggested that a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early/intermediate stage in NFT formation.
TTBK1 may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease in a Han Chinese population.
This study demonistrated that TTBK1 is a promising new candidate tau phosphorylation-related gene for Alzheimer's disease risk.
TTBK1 in AD brain may be one of the underlying mechanisms inducing CDK5 (show CDK5 Proteins) and calpain activation, NR2B (show GRIN2B Proteins) downregulation, and subsequent memory dysfunction.
TTBK1 accelerates motor neuron neurodegeneration by recruiting proinflammatory monocytes and enhancing sensitivity to neurotoxicity in inflammatory conditions.
TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model.
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
tau-tubulin kinase 1
, brain-derived tau kinase