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tau Tubulin Kinase 1 Proteins (Ttbk1)

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Additionally we are shipping tau Tubulin Kinase 1 Antibodies (61) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Ttbk1 84630 Q5TCY1
Ttbk1 106763 Q6PCN3
Rat Ttbk1 Ttbk1 316229  
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Top tau Tubulin Kinase 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

Ttbk1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for tau Tubulin Kinase 1 (Ttbk1) Interaction Partners

Human tau Tubulin Kinase 1 (Ttbk1) interaction partners

  1. TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 (show TARDBP Proteins) proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP.

  2. X-ray diffraction data were collected and the structure of TTBK1 was determined by molecular replacement both as an apo (show C9orf3 Proteins) structure and in complex with a kinase inhibitor

  3. The study suggested that a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early/intermediate stage in NFT formation.

  4. TTBK1 may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease in a Han Chinese population.

  5. This study demonistrated that TTBK1 is a promising new candidate tau phosphorylation-related gene for Alzheimer's disease risk.

  6. TTBK1 in AD brain may be one of the underlying mechanisms inducing CDK5 (show CDK5 Proteins) and calpain activation, NR2B (show GRIN2B Proteins) downregulation, and subsequent memory dysfunction.

Mouse (Murine) tau Tubulin Kinase 1 (Ttbk1) interaction partners

  1. TTBK1 accelerates motor neuron neurodegeneration by recruiting proinflammatory monocytes and enhancing sensitivity to neurotoxicity in inflammatory conditions.

  2. TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model.

tau Tubulin Kinase 1 (Ttbk1) Protein Profile

Protein Summary

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

Gene names and symbols associated with tau Tubulin Kinase 1 Proteins (Ttbk1)

  • tau tubulin kinase 1 (TTBK1)
  • tau tubulin kinase 1 (Ttbk1)
  • AU017937 protein
  • AW048023 protein
  • BDTK protein
  • C330008L01Rik protein
  • RGD1559518 protein

Protein level used designations for tau Tubulin Kinase 1 Proteins (Ttbk1)

tau-tubulin kinase 1 , brain-derived tau kinase

GENE ID SPECIES
416713 Gallus gallus
84630 Homo sapiens
106763 Mus musculus
100684678 Canis lupus familiaris
100155509 Sus scrofa
786439 Bos taurus
316229 Rattus norvegicus
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