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Browse our CYP11B2 Proteins (CYP11B2)

Full name:
Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 Proteins (CYP11B2)
On www.antibodies-online.com are 3 Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) Proteins from 2 different suppliers available. Additionally we are shipping CYP11B2 Antibodies (55) and CYP11B2 Kits (5) and many more products for this protein. A total of 65 CYP11B2 products are currently listed.
Synonyms:
ALDOS, Cp11ba, Cp45as, Cpn2, Cyp11b, Cyp11b-2, cyp11b2, Cyp11b3, CYP11BL, CYPXIB2, P-450C18, P450aldo, P450C18, RATCP11BA, RNCP45AS
list all proteins Gene Name GeneID UniProt
CYP11B2 500892  
CYP11B2 1585 P19099
CYP11B2 13072 P15539

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CYP11B2 Proteins (CYP11B2) by Origin

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More Proteins for CYP11B2 Interaction Partners

Zebrafish Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

  1. Data show that cytochrome P450 enzymes Cyp17 (show CYP17A1 Proteins)-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (show FOXO4 Proteins) Foxl2a were detected both in the testis and ovary.

Human Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

  1. The present study revealed a strong synergistic effect of CYP11B2 C-344T and IC polymorphisms causing susceptibility to EHT (show CBFA2T2 Proteins) and haplotype H1 (-344T-Conv-Lys173) as the risk-conferring factor for hypertension predisposition.

  2. Deletions, duplications or chimeric CYP11B2/CYP11B1 (show CYP11B1 Proteins) gene is associated with 11beta-hydroxylase deficiency.

  3. CYP11B2 T-344C single nucleotide polymorphism exhibited a strong association with the development of coronary artery disease in Taiwanese women.

  4. aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.

  5. There is lack of association between C-344T polymorphism of CYP11B2 gene and Essential Hypertension in Dongxiang and Han populations from northwest of China , whereas the polymorphism was correlated in female population of Tibetan.

  6. Polymorphisms of three genes (ACE (show ACE Proteins), AGT (show AGXT Proteins) and CYP11B2) in the renin (show REN Proteins)-angiotensin-aldosterone system are not associated with blood pressure salt sensitivity. (Meta-analysis)

  7. Gene polymorphism of CYP11B2 (-344C>T) may be associated with developing preeclampsia during pregnancy.

  8. This meta-analysis is purposed to reveal the relationship between the -344C/T aldosterone synthase variant and the left ventricular structure and function.

  9. Strong synergistic effect between ACE (show ACE Proteins) and CY11B2 gene polymorphisms in the molecular pathogenesis of Essential Hypertension in Kazakhs in Xinjiang was identified.

  10. Adrenal tumors in patients with primary aldosteronism can demonstrate clear heterogeneity in cytochrome P450 family 11 subfamily B member 2 (CYP11B2) expression and somatic mutations in driver genes for aldosterone production

Mouse (Murine) Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

  1. Aldosterone synthase knockout mouse shows odium-induced endothelial sodium channel up-regulation in vascular endothelium

  2. Aldosterone synthase (CYP11B2) is a key regulator of fibrotic remodeling during atrial fibrillation.

  3. Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1 (show NR5A1 Proteins)

  4. Modest increase in aldosterone synthase (AS) expression makes blood pressure more sensitive to salt in mice, suggesting that genetically increased AS expression in humans may contribute to hypertension and cardiovascular complication with high-salt diets.

Cow (Bovine) Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 (CYP11B2) interaction partners

  1. Fetal adrenal cells in primary culture respond to angiotensin-II (or synthetic ACTH (show POMC Proteins)) by increasing aldosterone production and aldosterone synthase [P450c18/CYP11B2] activity.

CYP11B2 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

Alternative names and synonyms associated with CYP11B2

  • aldosterone synthase (Cyp11b2)
  • cytochrome P450, family 11, subfamily B, polypeptide 2 (CYP11B2)
  • cytochrome P450, family 11, subfamily C, polypeptide 1 (cyp11c1)
  • cytochrome P450, family 11, subfamily b, polypeptide 1 (Cyp11b1)
  • cytochrome P450, family 11, subfamily b, polypeptide 2 (Cyp11b2)
  • cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 (CYP11B2)
  • ALDOS protein
  • Cp11ba protein
  • Cp45as protein
  • Cpn2 protein
  • Cyp11b protein
  • Cyp11b-2 protein
  • cyp11b2 protein
  • Cyp11b3 protein
  • CYP11BL protein
  • CYPXIB2 protein
  • P-450C18 protein
  • P450aldo protein
  • P450C18 protein
  • RATCP11BA protein
  • RNCP45AS protein

Protein level used designations for CYP11B2

cytochrome P450 11B2, mitochondrial , cytochrome P450, family 11, subfamily B, polypeptide 2 , cyp11b , cytochrome P45011B , CYPXIB1 , Cytochrome P450, subfamily XIB, polypeptide 1 (steroid 11-beta-hydroxylase) , P450(11 beta)-DS , P450C11 , aldosterone synthase , cytochrome P450 11B1, mitochondrial , cytochrome P450(11 beta)-DS , cytochrome P450, subfamily 11B, polypeptide 1 , cytochrome P450C11 , steroid 11-beta-hydroxylase , aldosterone-synthesizing enzyme , cytochrome P-450Aldo , cytochrome P-450C18 , cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2 , mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2 , steroid 11-beta-monooxygenase , steroid 11-beta/18-hydroxylase , steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo , CYPXIB2 , steroid-11-beta-hydroxylase , CYPXIB3 , Cytochrome P450 subfamily XIB polypeptide 2 (aldosterone synthase) , Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase) , P450-Aldo-1 , P450-Aldo-2 , cytochrome P450 11B3, mitochondrial , cytochrome P450, subfamily 11B, polypeptide 2 , cytochrome P450-Aldo-1 , cytochrome P450-Aldo-2 , mitochondrial cytochrome P450 11B2

GENE ID SPECIES
100379213 Cavia porcellus
695914 Macaca mulatta
791124 Danio rerio
100328543 Oryctolagus cuniculus
500892 Rattus norvegicus
1585 Homo sapiens
13072 Mus musculus
24294 Rattus norvegicus
482071 Canis lupus familiaris
282423 Bos taurus
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