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Human T-lymphotropic virus 1 Tax (show CNTN2 Proteins) protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 (show TBK1 Proteins) to evade host innate immunity.
STING activated an antiviral/type I interferon (show IFNA Proteins) response with live but not killed S. aureus.
study identifies the AIM2 (show AIM2 Proteins) inflammasome and cGAS/IFI16 (show IFI16 Proteins)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
NEMO (show IKBKG Proteins) was critically involved in the cGAS-STING pathway.
Studied association of genetic variants of the MAVS, MITA and MFN2 genes with leprosy in Han Chinese from Southwest China; found no association between the variants and susceptibility to leprosy.
both IL-6 (show IL6 Proteins) and RIG-I (show DDX58 Proteins) are downstream molecules of STING along the DNA sensor pathway.
We discuss three newly described monogenic autoinflammatory diseases [deficiency of adenosine deaminase 2 (show CECR1 Proteins) (DADA2), a subtype of macrophage activation syndrome (MAS (show MAS1 Proteins)), and stimulator of interferon (show IFNA Proteins) genes (STING)-associated vasculopathy with onset in infancy (SAVI)], discuss the possibilities of somatic mosaicism and digenic inheritance, and give an update on new concepts in pathways involved in familial Mediterranean fever (show MEFV Proteins)
Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon (show IFNA Proteins) signaling
a critical role of p38 (show CRK Proteins)-mediated USP21 (show USP21 Proteins) phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (show CRK Proteins)-USP21 (show USP21 Proteins) axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
We conclude that the R71H-G230A-R293Q (HAQ) of TMEM173 is a null TMEM173 allele.
Data show that stimulator of interferon (show IFNA Proteins) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3 (show IRF3 Proteins)-independent immune cell dysregulation and lung disease in mice.
These results highlight the crucial role of MFN1 (show MFN1 Proteins) in maintaining the competency of the STING pathway.
to contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin (show BST2 Proteins), a viral restriction factor
found that CCCP impairs the interaction between STING and TBK1 (show TBK1 Proteins) and concomitantly triggers mitochondria fission.
Yersinia YopJ negatively regulates IRF3 (show IRF3 Proteins)-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
demonstrate that in colon tumor model, therapeutic anti-CD47 (show CD47 Proteins) preferentially relies on STING-mediated DNA sensing in dendritic cells
STING is a central mediator of interferon (show IFNA Proteins) regulated inflammasome activation in Chlamydia trachomatis infection.
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
transmembrane protein 173
, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
, endoplasmic reticulum IFN stimulator
, endoplasmic reticulum interferon stimulator
, mediator of IRF3 activation
, mitochondrial mediator of IRF3 activation
, stimulator of interferon genes protein
, Stimulator of interferon genes protein
, mitochondrial transmembrane protein 173