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our research demonstrated that NEAT1 acts as a key regulator in human ovarian carcinogenesis and revealed two regulatory factors (HuR and miR (show MLXIP ELISA Kits)-124-3p) of NEAT1 expression.
The crucial role of HuR as a stabilizing factor for the MR transcript.
study found cytoplasmic HuR is significantly overexpressed in higher-grade (atypical and anaplastic) than in lower-grade meningiomas and the HuR level is correlated with survival in patients with meningioma; siHuR-induced HuR knockdown was shown to reduce the growth of both Ben-Men-1 and IOMM-Lee cells
combined treatments of siHuR and epirubicin significantly reduced the expression of Bcl-2 (show BCL2 ELISA Kits), but increased the expression of Bax (show BAX ELISA Kits), as well as activity and expression levels of caspase-3 (show CASP3 ELISA Kits) and -9. In contrast, overHuR abrogated these effects
High HuR expression is associated with pancreatic ductal adenocarcinomas.
GPRC5A (show GPRC5A ELISA Kits) is a potential oncogene (show RAB1A ELISA Kits) in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR.
Hur role in the epithelial-to-mesenchymal transition in pancreatic cancer
exposing glioma cells to the HuR inhibitor tanshinone group compound 15,16-dihydrotanshinone-I or to the newly identified compound 5 disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.
We propose that the extensive binding of CircPABPN1 to HuR prevents HuR binding to PABPN1 (show PABPN1 ELISA Kits) mRNA and lowers PABPN1 (show PABPN1 ELISA Kits) translation, providing the first example of competition between a circRNA and its cognate mRNA for an RBP (show RBP4 ELISA Kits) that affects translation.
HuR contributes to efficient oxidative phosphorylation by regulating of CoQ10 biosynthesis.
STAU1 (show STAU1 ELISA Kits) & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development (show MTA2 ELISA Kits) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (show ELAVL2 ELISA Kits) mRNAs were detectable from the GV to the morula stage; ELAVL2 (show ELAVL2 ELISA Kits) protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (show RBM24 ELISA Kits) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 (show GATA1 ELISA Kits) expression.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin (show LEP ELISA Kits) mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 (show CCR6 ELISA Kits) expression by binding to and stabilizing Ccr6 (show CCR6 ELISA Kits) mRNA and by promoting Ccr6 (show CCR6 ELISA Kits) translation in helper T-cells; knock-out of HuR reduces Ccr6 (show CCR6 ELISA Kits) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 (show CCR6 ELISA Kits) = C-C chemokine receptor type 6 (show CCR6 ELISA Kits))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP (show FAP ELISA Kits))--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP (show FAP ELISA Kits) chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta (show GSK3b ELISA Kits) and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta (show GSK3b ELISA Kits) pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 (show CDC42 ELISA Kits) translation.
This study uncovers an anti-sense lncRNA (APOA4 (show APOA4 ELISA Kits)-AS), which is co-expressed with APOA4 (show APOA4 ELISA Kits), and concordantly and specifically regulates APOA4 (show APOA4 ELISA Kits) expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX (show ENPP2 ELISA Kits) expression by HuR and AUF1 (show HNRNPD ELISA Kits) modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Results indicate that HuR induces 14-3-3zeta (show YWHAZ ELISA Kits) translation via interaction with its 3' UTR (show UTS2R ELISA Kits) and that 14-3-3zeta (show YWHAZ ELISA Kits) is necessary for stimulation of intestinal epithelial cell migration after wounding.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein