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Quantitative PCR revealed significantly reduced LKB1 (show STK11 Proteins), MO25alpha (show CAB39 Proteins), and STRADbeta mRNA in LKB1 (show STK11 Proteins)(-/-) muscle. These findings demonstrate that the LKB1 (show STK11 Proteins)-MO25 (show CAB39 Proteins)-STRAD (show STRADA Proteins) complex is the principal AMPKK in skeletal muscle.
a novel XIAP (show XIAP Proteins)-interacting protein that acts as a co-factor enhancing XIAP (show XIAP Proteins)-mediated activation of JNK1 (show MAPK8 Proteins) and the caspase (show CASP3 Proteins)-independent protection of XIAP (show XIAP Proteins) against apoptosis
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
polyploidy associated protein kinase PAPK-A
, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2
, STE20-related kinase adaptor beta
, STE20-related kinase adapter protein beta
, juvenile amyotrophic lateral sclerosis 2 candidate 2
, STE20-related kinase adapter protein beta-like
, ILP-interacting protein homolog
, STRAD beta
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog
, polyploidy associated protein kinase
, polyploidy-associated protein kinase
, pseudokinase ALS2CR2
, ILP-interacting protein ILPIPA
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein