COL4a2 antibody (AA 1493-1712) (HRP)

Catalog No. ABIN1045419

Product Details anti-COL4a2 Antibody (HRP)

Target: COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))

Binding Specificity: AA 1493-1712

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4a2 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.
Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COL4a2

Target: COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))

Alternative Name: COL4A2 (COL4A2 Products)

Synonyms: col4a2-a antibody, zCanstatin antibody, ICH antibody, POREN2 antibody, Col4a-2 antibody, collagen, type IV, alpha 2 L homeolog antibody, collagen type IV alpha 2 chain antibody, collagen, type IV, alpha 2 antibody, col4a2.L antibody, COL4A2 antibody, col4a2 antibody, Col4a2 antibody

Background:

Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \\\'chicken-wire\\\' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

Aliases: Canstatin antibody, CO4A2_HUMAN antibody, COL4A 2 antibody, Col4a2 antibody, Collagen alpha 2(IV) chain antibody, Collagen, type IV, alpha 2 antibody

UniProt: P08572