COL4a2 antibody (AA 1493-1712) (FITC)
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- Target See all COL4a2 (COL4A2) Antibodies
- COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))
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Binding Specificity
- AA 1493-1712
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This COL4a2 antibody is conjugated to FITC
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Collagen alpha-2(IV) chain protein (1493-1712AA)
- Isotype
- IgG
- Top Product
- Discover our top product COL4A2 Primary Antibody
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- Application Notes
- Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid freeze and thaw cycles. Product is photosensitive and should be protected from light.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- COL4a2 (COL4A2) (Collagen, Type IV, alpha 2 (COL4A2))
- Alternative Name
- COL4A2 (COL4A2 Products)
- Synonyms
- col4a2-a antibody, zCanstatin antibody, ICH antibody, POREN2 antibody, Col4a-2 antibody, collagen, type IV, alpha 2 L homeolog antibody, collagen type IV alpha 2 chain antibody, collagen, type IV, alpha 2 antibody, col4a2.L antibody, COL4A2 antibody, col4a2 antibody, Col4a2 antibody
- Background
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Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \\\'chicken-wire\\\' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Aliases: Canstatin antibody, CO4A2_HUMAN antibody, COL4A 2 antibody, Col4a2 antibody, Collagen alpha 2(IV) chain antibody, Collagen, type IV, alpha 2 antibody
- UniProt
- P08572
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