TYK2 antibody (N-Term)
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- Target See all TYK2 Antibodies
- TYK2 (Tyrosine Kinase 2 (TYK2))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TYK2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- At least three isoforms of TYK2 are known to exist, this antibody only detects the two longest isoforms.
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- Rabbit polyclonal TYK2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TYK2.
- Isotype
- IgG
- Top Product
- Discover our top product TYK2 Primary Antibody
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- Application Notes
- TYK2 antibody can be used for detection of TYK2 by Western blot at 1 - 2 μg/mL.
- Comment
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(NT) Tyrosine kinase 2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Storage
- 4 °C
- Storage Comment
- TYK2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Expiry Date
- 12 months
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- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Alternative Name
- TYK2 (TYK2 Products)
- Synonyms
- JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody
- Background
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TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Synonyms: Tyrosine kinase 2, non-receptor tyrosine kinase 2 - Molecular Weight
- 131 kDa (calculated)
- Gene ID
- 7297
- NCBI Accession
- NP_003322
- Pathways
- JAK-STAT Signaling, Hepatitis C
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