CD6 antibody (CD6) (AA 472-668)

Details for Product anti-CD6 Antibody No. ABIN1098118, Supplier: Log in to see
Antigen
  • TP120
  • OX52
  • CD6 antigen
  • CD6 molecule
  • Cd6 molecule
  • Cd6
  • CD6
Epitope
AA 472-668
17
15
14
8
6
6
4
3
3
3
3
3
3
3
1
1
1
Reactivity
Human
302
72
57
8
8
2
2
2
2
2
2
Host
Mouse
313
54
39
3
Clonality (Clone)
Monoclonal ()
Conjugate
This CD6 antibody is un-conjugated
33
24
23
11
11
10
10
10
8
8
8
8
8
8
7
7
6
6
3
3
3
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
279
236
134
120
117
115
98
91
85
13
12
4
3
1
Options
Supplier
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Supplier Product No.
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Immunogen Purified recombinant fragment of human CD6 (AA 472-668) expressed in E. Coli.
Clone 6B9
Isotype IgG1
Purification Purified
Alternative Name CD6 (CD6 Antibody Abstract)
Background This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 71.8 kDa
Gene ID 923
HGNC 923
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
ELISA image for anti-CD6 (CD6) (AA 472-668) antibody (ABIN1098118) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Immunohistochemistry (IHC) image for anti-CD6 (CD6) (AA 472-668) antibody (ABIN1098118) Figure 2: Immunohistochemical analysis of paraffin-embedded stomach cancer tissues us...
Western Blotting (WB) image for anti-CD6 (CD6) (AA 472-668) antibody (ABIN1098118) Figure 3: Western blot analysis using CD6 mAb against human CD6 recombinant protein. ...
Western Blotting (WB) image for anti-CD6 (CD6) (AA 472-668) antibody (ABIN1098118) Figure 4: Western blot analysis using CD6 mAb against HEK293 (1) and CD6 (AA: 472-668...
Background publications Kofler, Severson, Mousissian, De Jager, Hafler: "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 6, pp. 3286-91, 2011 (PubMed).

De Jager, Jia, Wang, de Bakker, Ottoboni, Aggarwal, Piccio, Raychaudhuri, Tran, Aubin, Briskin, Romano, Baranzini, McCauley, Pericak-Vance, Haines, Gibson, Naeglin, Uitdehaag, Matthews, Kappos, Polman, McArdle, Strachan, Evans, Cross, Daly, Compston, Sawc: "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci." in: Nature genetics, Vol. 41, Issue 7, pp. 776-82, 2009 (PubMed).

Product cited in: Alonso, Buors, Le Dantec, Hillion, Pers, Saraux, Montero, Marianowski, Loisel, Devauchelle, Youinou, Renaudineau: "Aberrant expression of CD6 on B-cell subsets from patients with Sjögren's syndrome." in: Journal of autoimmunity, Vol. 35, Issue 4, pp. 336-41, 2010 (PubMed).

Sarrias, Farnós, Mota, Sánchez-Barbero, Ibáñez, Gimferrer, Vera, Fenutría, Casals, Yélamos, Lozano: "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 28, pp. 11724-9, 2007 (PubMed).

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