BCL10 antibody (B-Cell CLL/lymphoma 10)

Details for Product anti-BCL10 Antibody No. ABIN1105500, Supplier: Log in to see
Antigen
  • CARMEN
  • CIPER
  • CLAP
  • c-E10
  • mE10
  • BCL10
  • AI132454
  • BCL-10
  • C81403
  • ME10
  • cE10
  • bcl10
  • B-cell CLL/lymphoma 10
  • B cell leukemia/lymphoma 10
  • B-cell lymphoma/leukemia 10
  • BCL10
  • Bcl10
  • bcl10
  • LOC100223183
Alternatives
anti-Mouse (Murine) BCL10 antibody for Cytometry by Time of Flight
Reactivity
Human, Mouse (Murine)
300
93
48
2
2
1
1
1
1
1
1
1
Host
Mouse
174
123
4
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL10 antibody is un-conjugated
11
10
10
8
6
5
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
232
138
114
110
97
87
60
33
26
13
3
3
2
1
Options
Supplier
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Clone 4F8
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Purified
Alternative Name Bcl-10 (BCL10 Antibody Abstract)
Background Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10
Gene ID 8915
Research Area Cancer
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Flow Cytometry (FACS) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody
Western Blotting (WB) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 3)
Immunofluorescence (IF) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 4)
Background publications Lucas, Yonezumi, Inohara, McAllister-Lucas, Abazeed, Chen, Yamaoka, Seto, Nunez: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed).

Wang, Guo, Huang, Ke, Poyet, Manji, Merriam, Glucksmann, DiStefano, Alnemri, Bertin: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed).

Rudd: "Adaptors and molecular scaffolds in immune cell signaling." in: Cell, Vol. 96, Issue 1, pp. 5-8, 1999 (PubMed).