CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa)

Details for Product anti-CTNNB1 Antibody No. ABIN1105692, Supplier: Log in to see
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin (cadherin associated protein), beta 1
  • catenin (cadherin-associated protein), beta 1
  • CTNNB1
  • LOC100217813
  • Ctnnb1
  • ctnnb1
  • ctnnb1-a
  • ctnnb1-b
Alternatives
anti-Human CTNNB1 antibody for Enzyme Immunoassay
Reactivity
Chicken, Human, Rat (Rattus)
475
213
188
63
53
40
26
25
21
21
15
15
15
10
9
9
3
1
1
1
1
1
1
Host
Mouse
308
180
6
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CTNNB1 antibody is un-conjugated
14
11
8
7
6
6
4
4
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
438
154
126
123
111
98
69
31
15
13
8
8
4
3
3
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Recombinant chicken beta-catenin
Clone IMD-110
Isotype IgG1
Specificity This antibody reacts to Catenin beta-1.
Purification Affinity chromatography
Alternative Name Catenin beta-1 (CTNNB1 Antibody Abstract)
Background Three catenin proteins, alpha, beta and gamma, bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion. Not only associated with E-cadherin, alpha-catenin was also shown to associate with other members of the cadherin family, such as N-cadherin and P-cadherin. beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta-catenin has also been found in complexes with the tumor suppressor protein APC. γ-catenin, also known as plakoglobin, is a protein that binds with alpha-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling.Synonyms: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679
UniProt P35222
Research Area Signaling
Pathways WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Reconstitution Restore with 1.2 % sodium acetate or neutral PBS
Concentration 0,1 mg/mL
Buffer 1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Huelsken, Vogel, Erdmann, Cotsarelis, Birchmeier: "beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin." in: Cell, Vol. 105, Issue 4, pp. 533-45, 2001 (PubMed).

Ilyas, Tomlinson, Rowan, Pignatelli, Bodmer: "Beta-catenin mutations in cell lines established from human colorectal cancers." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 19, pp. 10330-4, 1997 (PubMed).

Bailey, Norris, Leek, Clissold, Carr, Ogilvie, Morrison, Meredith, Markham: "Yeast artificial chromosome cloning of the beta-catenin locus on human chromosome 3p21-22." in: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Vol. 3, Issue 3, pp. 201-3, 1995 (PubMed).

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